Knobil E, Plant T M, Wildt L, Belchetz P E, Marshall G
Science. 1980 Mar 21;207(4437):1371-3. doi: 10.1126/science.6766566.
In rhesus monkeys with hypothalamic lesions (which appear to abolish the endogenous production of gonadotropin-releasing hormone), normal ovulatory mestrual cycles were reestablished by an unvarying, long-term replacement regimen consisting of one intravenous pulse of synthetic gonadotropic-releasing hormone per hour. This finding is in accord with the hypothesis that the pattern of pituitary gonadotropin secretion throughout the menstrual cycle (basal secretion interrupted, once every 28 days on the average, by a preovulatory surge) is not directed by alterations in hypothalamic gonadotropin-releasing hormone secretion but by the ebb and flow of ovarian estrogens acting directly on the pituitary gland.
在患有下丘脑损伤的恒河猴（下丘脑损伤似乎会消除促性腺激素释放激素的内源性分泌）中，通过每小时静脉注射一次合成促性腺激素释放激素的恒定长期替代方案，重新建立了正常的排卵月经周期。这一发现与以下假设一致：整个月经周期中垂体促性腺激素分泌模式（基础分泌平均每28天被一次排卵前激增中断一次）并非由下丘脑促性腺激素释放激素分泌的变化所引导，而是由直接作用于垂体的卵巢雌激素的起伏所引导。
