Mikolich J R, Nicoloff N B, Robinson P H, Logue R B
Chest. 1980 Mar;77(3):375-9. doi: 10.1378/chest.77.3.375.
Seventy-five patients with chest pain due to prolonged myocardial ischemia (group I, n=45) or acute myocardial infaction (group II, n=30) were treated with continuous intravenous infusion of nitroglycerin. Pain relief was achieved immediately or after titration in 40 of 45 group I patients and 22 of 30 group II patients. Of the 29 group I patients who received narcotic analgesics for pain relief prior to the nitroglycerin infusion, 20 experienced a decrease in narcotics required for pain relief while intravenously receiving nitroglycerin. Twenty-four of 28 group I patients and 14 of 19 group II patients who had angina refractory to multiple doses of sublingual nitroglycerin received relief with intravenous administration of nitroglycerin. This data suggests that intravenous administration of nitroglycerin is useful, adjunctive therapy for chest pain even when refractory to multiple doses of sublingual nitroglycerin.
75例因长期心肌缺血导致胸痛的患者（I组，n = 45）或急性心肌梗死患者（II组，n = 30）接受了硝酸甘油持续静脉输注治疗。I组45例患者中有40例、II组30例患者中有22例在即刻或滴定后疼痛得到缓解。在I组29例在输注硝酸甘油前接受麻醉性镇痛药缓解疼痛的患者中，有20例在静脉输注硝酸甘油时所需的镇痛药剂量减少。I组28例中有24例、II组19例中有14例对多次舌下含服硝酸甘油无效的心绞痛患者，静脉给予硝酸甘油后疼痛得到缓解。这些数据表明，即使对多次舌下含服硝酸甘油无效，静脉给予硝酸甘油仍是治疗胸痛的有效辅助疗法。
