Bestetti G, Fatzer R, Frankhauser R
Acta Neuropathol. 1978 Aug 7;43(1-2):69-75. doi: 10.1007/BF00685000.
A 4-month-old, male, healthy dog developed CNS-symptoms 10 days after the second vaccination with live, attenuated distemper and canine hepatitis virus. The animal was euthanized after 2 weeks of illness. Light and electron microscopic examination of the CNS showed a partly necrotizing encephalomyelitis with numberous intranuclear and intracytoplasmic inclusion bodies, and the presence of probable pseudomyxovirus nucleocapsids and of crystalloid and tubuloreticular aggregates. Although there was conformity of inclusion bodies and probable viral structures as revealed by electron microscopy, the latter showed a much wider distribution. In addition, viral structures of a different type were found in polymorphonuclear leukocytes and vascular endothelial cells. Several morphological criteria led to the supposition that they are Picornaviruses, or possibly Arenaviruses. It is thought that their role in the disease process was at best an indirect one.
一只4个月大的健康雄性犬在第二次接种减毒活犬瘟热病毒和犬肝炎病毒疫苗10天后出现中枢神经系统症状。患病2周后对该动物实施了安乐死。对中枢神经系统进行光镜和电镜检查发现，存在部分坏死性脑脊髓炎，伴有大量核内和胞质内包涵体，以及可能的副粘病毒核衣壳、晶体样和管网状聚集体。尽管电镜显示包涵体和可能的病毒结构一致，但后者分布更为广泛。此外，在多形核白细胞和血管内皮细胞中发现了不同类型的病毒结构。根据多项形态学标准推测，它们是微小核糖核酸病毒，也可能是沙粒病毒。据认为，它们在疾病过程中的作用充其量只是间接的。
