Dostálek C, Jokl J, Koch E, Krása H
Physiologie. 1980 Jan-Mar;17(1):45-56.
Excretion of catecholamines, DOPA and their oxidoreduction states were studied during aversive conditioning in a 10-sitting experiment in man. Urinary samples in 3 intervals of 8 h. before respective sitting and 20, 80 and 200 minutes after the sitting. The initial unspecific phase of conditioning corresponds to an increase and decrease of catecholamine elimination characterized by a prevailing of adrenaline and noradrenaline (interpreted as the same change in level of unconditioned excitability). In the specific phase of conditioning more important participation of dopamine and probably DOPA and their metabolites were observed. The anticipatory conditioned reflex itself (manifested in urinary samples before resp. sittings) is characterized by surplus of adrenaline and noradrenaline. The results support our conception of two phases in conditioning (and generally learning) process.
在一项针对人类的为期10次的厌恶条件反射实验中，研究了儿茶酚胺、多巴及其氧化还原状态的排泄情况。在每次实验前8小时的3个时间段以及实验后20、80和200分钟收集尿液样本。条件反射最初的非特异性阶段表现为儿茶酚胺排泄的先增加后减少，其特征是肾上腺素和去甲肾上腺素占优势（解释为非条件兴奋性水平的相同变化）。在条件反射的特异性阶段，观察到多巴胺以及可能的多巴及其代谢产物的参与更为重要。预期性条件反射本身（体现在每次实验前的尿液样本中）的特征是肾上腺素和去甲肾上腺素过剩。这些结果支持了我们关于条件反射（以及一般学习）过程分为两个阶段的概念。
