与可结晶的冷沉淀性IgG副蛋白相关的关节炎。

Arthritis associated with a crystallizing cryoprecipitable IgG paraprotein.

作者信息

Langlands D R, Dawkins R L, Matz L R, Cobain T J, Goatcher P, Papadimitriou J M, Cohen M L

出版信息

Am J Med. 1980 Mar;68(3):461-5. doi: 10.1016/0002-9343(80)90122-9.

Abstract

A crystallizing IgG-lambda cryoprotein was found in the synovial fluid of a patient with peripheral erosive arthritis and tenosynovitis. The same crystallizing paraprotein could be demonstrated in serum incubated at 4 degrees C, but its formation could be inhibited by the in vitro addition of D-penicillamine. Crystals were present in synovial tissue and appeared to be initiating an inflammatory reaction via complement activation. Slit lamp examination showed crystals in Bowman's membrane. Plasmapheresis led to temporary improvement in the synovitis and tenosynovitis.

摘要

在一名患有外周侵蚀性关节炎和腱鞘炎的患者的滑液中发现了一种结晶性IgG-λ冷球蛋白。在4℃孵育的血清中也可检测到相同的结晶性副蛋白，但其形成可通过体外添加D-青霉胺来抑制。滑膜组织中存在晶体，似乎通过补体激活引发炎症反应。裂隙灯检查显示鲍曼膜中有晶体。血浆置换使滑膜炎和腱鞘炎暂时改善。