Iwata T, Kamei T, Uchino F, Mimaya H, Yanagaki T, Etoh H
Acta Pathol Jpn. 1978 Mar;28(2):193-203. doi: 10.1111/j.1440-1827.1978.tb00531.x.
Senile aortic amyloidosis in 224 autopsy cases over 40 years was investigated comparing cardiac and pancreatic amyloidosis in them. A total of 176 cases of aortic amyloidosis was found for an average incidence of 79%. Under the 5th decade the incidence was 51% and it rose sharply with age and reached 95% in over the 8th decade. The incidence of cardiac amyloidosis also increased with age, but it was always higher in the aorta. Aortic and cardiac amyloid were both positive in the DMAB method for tryptophan. The major part exposed to amyloidosis in the aorta was the media. The medial amyloid consisted of numerous minute deposits and had no relation to atherosclerosis. Some comments about the pathogenesis of senile amyloidosis were also mentioned.
对40多年来224例尸检病例中的老年主动脉淀粉样变性进行了研究，并比较了其中的心脏和胰腺淀粉样变性。共发现176例主动脉淀粉样变性病例，平均发病率为79%。在50岁以下，发病率为51%，并随年龄急剧上升，在80岁以上达到95%。心脏淀粉样变性的发病率也随年龄增加，但在主动脉中总是更高。主动脉和心脏淀粉样蛋白在检测色氨酸的DMAB方法中均呈阳性。主动脉中发生淀粉样变性的主要部位是中膜。中膜淀粉样蛋白由大量微小沉积物组成，与动脉粥样硬化无关。还提到了一些关于老年淀粉样变性发病机制的评论。
