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水杨酸钠对犬血浆胰岛素浓度和脂肪酸周转率的影响。

Effects of sodium salicylate on plasma insulin concentration and fatty acid turnover in dogs.

作者信息

Vik-Mo H, Hove K, Mjøs O D

出版信息

Acta Physiol Scand. 1978 Jun;103(2):113-9. doi: 10.1111/j.1748-1716.1978.tb06198.x.

DOI:10.1111/j.1748-1716.1978.tb06198.x
PMID:676763
Abstract

The effects of intravenous sodium salicylate administration on plasma concentrations of insulin, free fatty acids (FFA) and glucose were studied in intact, anaesthetized dogs both during basal and isoprenaline stimulated lipolysis. In both situations sodium salicylate reduced the plasma concentrations of insulin. The reduction was associated with decreased plasma FFA concentrations and FFA turnover rate, while plasma glucose concentrations remained unaltered. The reduced plasma insulin concentrations effected by sodium salicylate is most likely secondary to the concomitant fall in plasma FFA concentrations due to inhibition of FFA mobilization from adipose tissue.

摘要

在基础状态和异丙肾上腺素刺激脂肪分解过程中,对完整的麻醉犬静脉注射水杨酸钠,研究其对胰岛素、游离脂肪酸(FFA)和葡萄糖血浆浓度的影响。在这两种情况下,水杨酸钠均降低了胰岛素的血浆浓度。这种降低与血浆FFA浓度和FFA周转率的降低相关,而血浆葡萄糖浓度保持不变。水杨酸钠导致的血浆胰岛素浓度降低很可能继发于由于抑制脂肪组织中FFA的动员而导致的血浆FFA浓度的同时下降。

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