Vik-Mo H, Mjøs O D
Scand J Clin Lab Invest. 1977 Jun;37(4):287-94. doi: 10.3109/00365517709092631.
The effect of sodium salicylate and acetylsalicylic acid (ASA) on myocardial ischaemic injury following acute coronary artery occlusion has been studied in thoracotomized dogs during basal conditions and during elevation of plasma free fatty acid (FFA) concentration induced by intravenous (i.v.) infusion of isoprenaline (0.075-0.15 microgram/kg/min). Ischaemic injury was measured as the sum of ST-segment elevations (sigmaST) in epicardial ECG recordings from 10-15 sites 15 min after occlusion. Both sodium salicylate and ASA (60 mg/kg) significantly reduced sigmaST both before and during isoprenaline infusion. Arterial concentrations of FFA were reduced by either drug during isoprenaline infusion, whereas in the basal state only a significant effect by sodium salicylate could be demonstrated. The reduction in epicardial ST-segment elevation during coronary occlusion could not be explained by reduced mechanical activity of the heart. It is suggested that the reduction by salicylates of myocardial ischaemic injury might be related to reduced utilization of FFA by the myocardium, although a FFA-nondependent mechanism cannot be excluded in the basal state.
在基础状态以及静脉输注异丙肾上腺素（0.075 - 0.15微克/千克/分钟）诱导血浆游离脂肪酸（FFA）浓度升高期间，对开胸犬急性冠状动脉闭塞后水杨酸钠和乙酰水杨酸（ASA）对心肌缺血性损伤的影响进行了研究。缺血性损伤以闭塞15分钟后10 - 15个部位的心外膜心电图记录中ST段抬高总和（σST）来衡量。水杨酸钠和ASA（60毫克/千克）在异丙肾上腺素输注前和输注期间均显著降低了σST。在异丙肾上腺素输注期间，两种药物均降低了FFA的动脉浓度，而在基础状态下，仅水杨酸钠有显著作用。冠状动脉闭塞期间心外膜ST段抬高的降低不能用心脏机械活动的降低来解释。提示水杨酸盐对心肌缺血性损伤的降低作用可能与心肌对FFA利用的减少有关，尽管在基础状态下不能排除非FFA依赖性机制。
