Steinherz P G, Rosen G, Ghavimi F, Wang Y, Miller D R
J Pediatr. 1980 May;96(5):923-7. doi: 10.1016/s0022-3476(80)80583-x.
To evaluate the efficacy of lithium carbonate in ameliorating leukopenia, 37 patients (3 to 26 years old, mea (less than or equal to 1,000/mm3) over 40% of the time were designated at random on the last day of 82 separate chemotherapy courses to receive lithium or no treatment. Four could not take the drug because of the size of the capsules. There were 39 controls and 39 patients given lithium. Blood levels were maintained at 0.2 to 1.2 mEq/1 (median 0.7). The median drop of WBC in the treated group was 3,400/mm3 with a nadir of 1,800/mm3 vs 5,000 and 1,400, respectively, for the untreated patients (P LESS THAN 0.01). Eight patients (21%) in the lithium-treated group became severly leukopenic (less than or equal to 1,000/mm3) while 14 (36%) in the control group became leukopenic to that extent. Twenty-four patient days were spent with the WBC less than or equal to 1,000/mm3 after lithium and 57 days in the control group. Three patients required admission for 24 hospital days for fever while leukopenic after lithium, whereas seven patients spent 62 days in the hospital in the control group. Lithium reduces the period of leukopenia after chemotherapy during which time the patients may acquire infections.
为评估碳酸锂改善白细胞减少症的疗效，在82个独立化疗疗程的最后一天，将37例患者（年龄3至26岁，平均年龄12岁）随机分为两组，一组接受碳酸锂治疗，另一组不接受治疗，白细胞计数低于或等于1000/mm³的时间超过40%。有4例患者因胶囊尺寸问题无法服用该药物。对照组39例，碳酸锂治疗组39例。血药浓度维持在0.2至1.2 mEq/L（中位数0.7）。治疗组白细胞计数的中位数下降为3400/mm³，最低点为1800/mm³，而未治疗患者分别为5000/mm³和1400/mm³（P＜0.01）。碳酸锂治疗组有8例患者（21%）出现严重白细胞减少（低于或等于1000/mm³），而对照组有14例（36%）出现如此程度的白细胞减少。碳酸锂治疗后有24个患者日白细胞计数低于或等于1000/mm³，对照组为57个患者日。碳酸锂治疗后有3例患者因发热在白细胞减少期间住院24天，而对照组有7例患者住院62天。碳酸锂可缩短化疗后白细胞减少的持续时间，在此期间患者可能发生感染。
