Rolland P H, Martin P M, Jacquemier J, Rolland A M, Toga M
J Natl Cancer Inst. 1980 May;64(5):1061-70.
Prostaglandin (PG) production by human breast cancers was investigated in 91 lesions selected so that the distribution of histologic type was similar to that of the general population of mammary carcinomas. With regard to the shape characteristics of the tumors, PG production was higher in lesions classified T1 and T2 than in lesions classified T3 and T4 (T-classification is based on extent of tumor as graded by the International Union Against Cancer), higher in tumors exhibiting a high cellularity than in lesions with a low tumor cell density and higher in tumors in which the cells were still adherent to each other. A high PG production was associated with the presence of neoplastic cells in tumor lymphatic and blood vessels and in axillary lymph nodes. PG production by node metastases was always higher than that by the primary tumor sites. The analysis of the stroma reaction and the presence of edema and necrosis suggest that an active PG synthesis occurred in lesions in which the tumor cell-surrounding stroma presented characteristics of low resistance to invasive growth of cancer cells. With regard to histologic differentiation and histoprognostic grade of lesions, PG production was elevated in carcinomas that retained a minute part of the acinoductal differentiation and in tumors with a moderate or high degree of cancer. A lesion containing a steroid receptor (SR) tended to produce less PG than did an SR-negative tumor. PG production increased slightly according to ages and times of menopause of the patients. PG production occurred early in the natural course of breast cancer and was elevated in tumors at a time when active tumor invasion proceeded. By contrast, PG production decreased later in the course of tumor development. These results indicated that elevated PG production can be used as a marker of high metastatic potential for neoplastic cells in breast cancer.
对91例人类乳腺癌病变进行了前列腺素（PG）生成的研究，这些病变的选择使得组织学类型的分布与乳腺癌总体人群的分布相似。关于肿瘤的形态特征，T1和T2分类的病变中PG生成高于T3和T4分类的病变（T分类基于国际抗癌联盟分级的肿瘤范围），细胞密度高的肿瘤中PG生成高于肿瘤细胞密度低的病变，细胞仍相互黏附的肿瘤中PG生成也更高。PG生成高与肿瘤淋巴管、血管及腋窝淋巴结中存在肿瘤细胞有关。淋巴结转移灶的PG生成总是高于原发肿瘤部位。对间质反应以及水肿和坏死的存在情况进行分析表明，在肿瘤细胞周围间质呈现出对癌细胞侵袭性生长低抗性特征的病变中发生了活跃的PG合成。关于病变的组织学分化和组织预后分级，保留微小腺管分化部分的癌以及中度或高度癌症的肿瘤中PG生成升高。含有类固醇受体（SR）的病变往往比SR阴性肿瘤产生的PG少。PG生成根据患者的年龄和绝经时间略有增加。PG生成在乳腺癌自然病程早期就已出现，并且在肿瘤活跃侵袭进展时的肿瘤中升高。相比之下，在肿瘤发展过程后期PG生成下降。这些结果表明，PG生成升高可作为乳腺癌肿瘤细胞高转移潜能的标志物。
