Wang C, Ng R P, Chan T K, Todd D
Cancer. 1980 Apr 15;45(8):2030-7. doi: 10.1002/1097-0142(19800415)45:8<2030::aid-cncr2820450807>3.0.co;2-s.
After at least four courses of intermittent chemotherapy, 14 of the 15 men with malignant lymphoma had elevated serum follicle-stimulating hormone (FSH). In three of these subjects, serial studies showed progressive increases in basal FSH and exaggerated FSH responses to luteinizing hormone releasing hormone (LHRH). Although gonadal biopsies were not done, this elevation of FSH is indicative of progressive and severe damage to the germinal epithelium by chemotherapy. Elevated leutinizing hormone (LH) was found in seven and decreased testosterone (T) in two of these subjects. Increased LH responses to LHRH stimulation were also found in the three subjects studied. These findings suggest that the testicular damage is not restricted to the germinal tissue. In four male subjects with acute myeloid leukemia treated by intermittent chemotherapy not containing any alkylating agents, FSH, LH, and T levels were normal. Three of the 4 female patients with malignant lymphoma and two with acute myeloid leukemia had normal basal, serial, and LHRH-stimulated FSH, LH, and estradiol (E2) levels. Elevated gonadotropins and low E2 were found only in subjects who had received abdominal irradiation.
在接受至少四个疗程的间歇性化疗后，15名恶性淋巴瘤男性患者中有14名血清促卵泡激素（FSH）升高。在其中3名受试者中，系列研究显示基础FSH逐渐升高，且对促黄体生成素释放激素（LHRH）的FSH反应增强。尽管未进行性腺活检，但FSH升高表明化疗对生精上皮造成了进行性严重损害。在这些受试者中，7名促黄体生成素（LH）升高，2名睾酮（T）降低。在接受研究的3名受试者中，还发现对LHRH刺激的LH反应增强。这些发现表明，睾丸损伤并不局限于生精组织。在4名接受不含任何烷化剂的间歇性化疗的急性髓系白血病男性受试者中，FSH、LH和T水平正常。4名恶性淋巴瘤女性患者中的3名以及2名急性髓系白血病女性患者的基础、系列及LHRH刺激后的FSH、LH和雌二醇（E2）水平均正常。仅在接受腹部放疗的受试者中发现促性腺激素升高和E2降低。
