Sikora L K, Levy J G
J Immunol. 1980 Jun;124(6):2615-9.
The genetics of the immune response in the mouse were studied by using the antigenically simple, stable, naturally occurring protein ferredoxin (Fd) from Clostridium pasteurianum. The immune status of mice primed and boosted with Fd was assessed by using two parameters of immunity: T cell proliferation and serum antibody production with the ELISA method. In both assay systems, the response has been shown to be H-2 linked: k, b, and s haplotypes respond to Fd, and H-2d mice are nonresponders. It is apparent that different immunoregulatory events modulate the response in the responder strains; these factors become evident in the recombinant analysis of the response and to date an immunoregulatory gene(s) has been mapped to at least the K/I-A subregions. F1 analysis demonstrated a gene dose-dependent response of the strains studied.
通过使用来自巴氏芽孢杆菌的抗原性简单、稳定的天然存在蛋白质铁氧化还原蛋白（Fd），对小鼠免疫反应的遗传学进行了研究。用Fd进行初次免疫和加强免疫的小鼠的免疫状态通过两个免疫参数进行评估：T细胞增殖和采用ELISA法检测血清抗体产生。在这两种检测系统中，反应均显示与H-2相关：k、b和s单倍型对Fd有反应，而H-2d小鼠无反应。显然，不同的免疫调节事件调节了反应品系中的反应；这些因素在反应的重组分析中变得明显，迄今为止，一个免疫调节基因已至少定位到K/I-A亚区。F1分析表明所研究品系存在基因剂量依赖性反应。
