Robbins K R, Baker D H, Finley J W
J Nutr. 1980 May;110(5):907-15. doi: 10.1093/jn/110.5.907.
Studies were conducted to determine the nutritional value of lysinoalanine for rats and chicks and the nutritional value of lanthionine for chicks. For each experiment, purified crystalline amino acid diets and crystalline lysinoalanine and lanthionine were employed. Results indicated that the lysine moiety of lysinoalanine is completely unavailable to the rat and only partially available to the chick. Of 10 rats fed lysinoalanine, seven developed nephrocytomegaly. The lanthionine studies indicated that the cysteine moiety of lanthionine is 32% available when fed as the racemic mixture and 52% available when fed as the L-DL-isomeric mixture. Thus, it appears that lysinoalanine formation in alkali-treated proteins results in a corresponding decrease in nutritionally available lysine. However, the lanthionine formed under similar conditions results in loss of only one-half of the corresponding level of nutritionally available cysteine.
开展了多项研究以确定赖氨酸丙氨酸对大鼠和雏鸡的营养价值以及羊毛硫氨酸对雏鸡的营养价值。在每项实验中，均使用了纯化的结晶氨基酸日粮以及结晶赖氨酸丙氨酸和羊毛硫氨酸。结果表明，赖氨酸丙氨酸中的赖氨酸部分对大鼠完全不可利用，对雏鸡仅部分可利用。在喂食赖氨酸丙氨酸的10只大鼠中，有7只出现了肾细胞肿大。羊毛硫氨酸的研究表明，当以消旋混合物形式喂食时，羊毛硫氨酸中的半胱氨酸部分有32%可利用，当以L-DL-异构体混合物形式喂食时，有52%可利用。因此，看来碱处理蛋白质中形成的赖氨酸丙氨酸会导致营养上可利用的赖氨酸相应减少。然而，在类似条件下形成的羊毛硫氨酸只会导致相应水平的营养上可利用的半胱氨酸损失一半。
