Yoshida H, Kadota A, Fukunishi R, Matsumoto K
J Natl Cancer Inst. 1980 May;64(5):1105-12.
Effects of neonatal androgenization on 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumorigenesis infemale noninbred Sprague-Dawley rats are reported. Testosterone propionate (1.25 mg) was injected sc into 29 2-day-old rats. At 50 days of age, all rats were given 20 mg of DMBA through a stomach tube. In these androgenized rats, no corpora lutea were found in the ovaries and the induction of mammary carcinoma by DMBA was strongly suppressed, whereas the induction of mammary dysplasia was significantly accelerated in comparison with the neonatally intact controls. Mammary dysplasia in the androgenized group varied widely, with two kinds of macroscopically detectable tumor-forming lesions (solid and cystic) and with microscopic characteristics of acinar adenosis, fibrotic adenosis, fibrosis, intraductal papillary proliferative lesions, and epithelial cysts. The earliest lesions of mammary dysplasia observed were acinar adenosis nodules and microcysts, both of which appeared as multifocal phenomena as early as 25 days after administration of DMBA.
报道了新生期雄激素化对7,12-二甲基苯并[a]蒽（DMBA）诱导的雌性非近交系斯普拉格-道利大鼠乳腺肿瘤发生的影响。将丙酸睾酮（1.25毫克）皮下注射到29只2日龄大鼠体内。在50日龄时，所有大鼠通过胃管给予20毫克DMBA。在这些雄激素化的大鼠中，卵巢中未发现黄体，DMBA诱导的乳腺癌被强烈抑制，而与新生期未处理的对照组相比，乳腺发育异常的诱导明显加速。雄激素化组的乳腺发育异常差异很大，有两种可通过肉眼检测到的肿瘤形成病变（实性和囊性），并具有腺泡性腺病、纤维化性腺病、纤维化、导管内乳头状增生性病变和上皮囊肿的微观特征。观察到的最早的乳腺发育异常病变是腺泡性腺病结节和微囊肿，两者早在给予DMBA后25天就表现为多灶性现象。
