• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

乳腺对致癌作用的易感性：I. 乳腺分化作为肿瘤发生率和病变类型的决定因素。

Susceptibility of the mammary gland to carcinogenesis: I Differentiation of the mammary gland as determinant of tumor incidence and type of lesion.

作者信息

Russo J, Wilgus G, Russo I H

出版信息

Am J Pathol. 1979 Sep;96(3):721-36.

PMID:112872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2042395/
Abstract

The influence of age and mammary gland differentiation on the incidence of tumors induced by 7,12-dimethylbenz(a)anthracene (DMBA) was studied by correlating the development of the mammary glands of 20-180-day-old, virgin Sprague-Dawley rats with the number and type of tumors induced by DMBA administered at those various ages. The number of terminal end buds (TEBs), terminal ducts (TDs), and alveolar buds (ABs)/sq mm and their DNA-labeling indices (DNA-LI) were determined. Highest density of TEB occurred when the rats were 20 days old, decreasing thereafter. DNA-LI ranged between 25.2 and 29 in TEB of rats aged 30-55 days, which was coincident with the highest incidence of carcinomas. With aging, the number of TEBs and their DNA-LI decreased and the number of TDs and ABs increased, although with a low DNA-LI, which correlated with a lower incidence of carcinomas and higher incidence of benign lesions.

摘要

通过将20至180日龄处女斯普拉格-道利大鼠乳腺的发育情况与在不同年龄给予7,12-二甲基苯并(a)蒽（DMBA）诱导的肿瘤数量和类型相关联，研究了年龄和乳腺分化对DMBA诱导肿瘤发生率的影响。测定了每平方毫米的终末芽（TEB）、终末导管（TD）和腺泡芽（AB）数量及其DNA标记指数（DNA-LI）。TEB的最高密度出现在大鼠20日龄时，此后逐渐下降。30至55日龄大鼠的TEB中，DNA-LI在25.2至29之间，这与癌的最高发生率一致。随着年龄增长，TEB的数量及其DNA-LI下降，TD和AB的数量增加，尽管DNA-LI较低，这与癌的较低发生率和良性病变的较高发生率相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/3d62ab701240/amjpathol00241-0096-j.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/134c7ee10b0e/amjpathol00241-0095-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/41b4cd6f7c63/amjpathol00241-0095-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/1db6e0790877/amjpathol00241-0095-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/c41ecf08c7c0/amjpathol00241-0095-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/ce3f2da7b8f2/amjpathol00241-0095-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/0e8455ae1678/amjpathol00241-0096-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/e0b464e42ceb/amjpathol00241-0096-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/df264f511fd4/amjpathol00241-0096-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/949ce6201889/amjpathol00241-0096-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/9af1756b892a/amjpathol00241-0096-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/773bbf430726/amjpathol00241-0096-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/579ed469deff/amjpathol00241-0096-g.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/f0c0ebe7a81e/amjpathol00241-0096-h.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/4b1835a8f4e3/amjpathol00241-0096-i.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/3d62ab701240/amjpathol00241-0096-j.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/134c7ee10b0e/amjpathol00241-0095-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/41b4cd6f7c63/amjpathol00241-0095-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/1db6e0790877/amjpathol00241-0095-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/c41ecf08c7c0/amjpathol00241-0095-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/ce3f2da7b8f2/amjpathol00241-0095-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/0e8455ae1678/amjpathol00241-0096-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/e0b464e42ceb/amjpathol00241-0096-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/df264f511fd4/amjpathol00241-0096-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/949ce6201889/amjpathol00241-0096-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/9af1756b892a/amjpathol00241-0096-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/773bbf430726/amjpathol00241-0096-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/579ed469deff/amjpathol00241-0096-g.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/f0c0ebe7a81e/amjpathol00241-0096-h.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/4b1835a8f4e3/amjpathol00241-0096-i.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca96/2042395/3d62ab701240/amjpathol00241-0096-j.jpg

相似文献

1
Susceptibility of the mammary gland to carcinogenesis: I Differentiation of the mammary gland as determinant of tumor incidence and type of lesion.乳腺对致癌作用的易感性：I. 乳腺分化作为肿瘤发生率和病变类型的决定因素。
Am J Pathol. 1979 Sep;96(3):721-36.
2
Developmental stage of the rat mammary gland as determinant of its susceptibility to 7,12-dimethylbenz[a]anthracene.大鼠乳腺的发育阶段作为其对7,12 - 二甲基苯并[a]蒽敏感性的决定因素。
J Natl Cancer Inst. 1978 Dec;61(6):1439-49.
3
Induction of mammary tumors in aging rats by 7,12-dimethylbenz[a]anthracene: role of DNA synthesis during carcinogenesis.7,12-二甲基苯并[a]蒽诱导老龄大鼠乳腺肿瘤：致癌过程中DNA合成的作用
J Natl Cancer Inst. 1980 Mar;64(3):519-21.
4
Susceptibility of the mammary gland to carcinogenesis. II. Pregnancy interruption as a risk factor in tumor incidence.乳腺对致癌作用的易感性。II. 妊娠中断作为肿瘤发生率的一个风险因素。
Am J Pathol. 1980 Aug;100(2):497-512.
5
Hormone prevention of mammary carcinogenesis by norethynodrel-mestranol.炔诺酮-炔雌醇对乳腺癌发生的激素预防作用。
Breast Cancer Res Treat. 1989 Oct;14(1):43-56. doi: 10.1007/BF01805975.
6
Influence of differentiation and cell kinetics on the susceptibility of the rat mammary gland to carcinogenesis.分化和细胞动力学对大鼠乳腺致癌易感性的影响。
Cancer Res. 1980 Aug;40(8 Pt 1):2677-87.
7
Susceptibility of the mammary gland to carcinogenesis. III. The cell of origin of rat mammary carcinoma.乳腺对致癌作用的易感性。III. 大鼠乳腺癌的起源细胞。
Am J Pathol. 1983 Oct;113(1):50-66.
8
Influence of caffeine on development of benign and carcinomatous mammary gland tumors in female rats treated with the carcinogens 7,12-dimethylbenz(a)anthracene and N-methyl-N-nitrosourea.咖啡因对用致癌物7,12-二甲基苯并(a)蒽和N-甲基-N-亚硝基脲处理的雌性大鼠良性和癌性乳腺肿瘤发生发展的影响。
Cancer Res. 1991 Jul 1;51(13):3399-404.
9
Basis of cellular autonomy in the susceptibility to carcinogenesis.细胞自主性在致癌易感性中的基础。
Toxicol Pathol. 1983;11(2):149-66. doi: 10.1177/019262338301100207.
10
Exposure of Sprague-Dawley rats to a 50-Hertz, 100-microTesla magnetic field for 27 weeks facilitates mammary tumorigenesis in the 7,12-dimethylbenz[a]-anthracene model of breast cancer.将斯普拉格-道利大鼠暴露于50赫兹、100微特斯拉的磁场中27周，可促进7,12-二甲基苯并[a]蒽乳腺癌模型中的乳腺肿瘤发生。
Cancer Res. 1999 Aug 1;59(15):3627-33.

引用本文的文献

1
Rat Models of Breast Cancer.乳腺癌大鼠模型
Adv Exp Med Biol. 2025;1464:123-148. doi: 10.1007/978-3-031-70875-6_8.
2
Molecular Pathways of Genistein Activity in Breast Cancer Cells.染料木黄酮在乳腺癌细胞中的作用分子途径。
Int J Mol Sci. 2024 May 20;25(10):5556. doi: 10.3390/ijms25105556.
3
MicroRNAs: A Link between Mammary Gland Development and Breast Cancer.微小 RNA：乳腺发育与乳腺癌之间的联系。

本文引用的文献

1
EFFECT OF PREGNANCY AND LACTATION ON GROWTH OF MAMMARY TUMOURS INDUCED BY 7,12-DIMETHLBENZ(A) ANTHRACENE (DMBA).妊娠和哺乳对7,12 - 二甲基苯并(a)蒽（DMBA）诱导的乳腺肿瘤生长的影响。
Br J Cancer. 1965 Mar;19(1):160-6. doi: 10.1038/bjc.1965.19.
2
Mammary carcinogenesis by 3-methylcholanthrene. II. Inhibitory effect of pregnancy and lactation on tumor induction.3-甲基胆蒽诱发的乳腺癌。II. 妊娠和哺乳期对肿瘤诱导的抑制作用。
J Natl Cancer Inst. 1960 Nov;25:991-1003.
3
Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression.
Int J Mol Sci. 2022 Dec 15;23(24):15978. doi: 10.3390/ijms232415978.
4
Induced mammary cancer in rat models: pathogenesis, genetics, and relevance to female breast cancer.诱导性乳腺癌大鼠模型：发病机制、遗传学及与女性乳腺癌的相关性。
J Mammary Gland Biol Neoplasia. 2022 Jun;27(2):185-210. doi: 10.1007/s10911-022-09522-w. Epub 2022 Jul 29.
5
Multivariate analysis of independent roles of socioeconomic status, occupational physical activity, reproductive factors, and postmenopausal hormonal therapy in risk of breast cancer.多变量分析社会经济地位、职业体力活动、生殖因素以及绝经后激素治疗在乳腺癌风险中的独立作用。
Breast Cancer Res Treat. 2022 Jun;193(2):495-505. doi: 10.1007/s10549-022-06571-x. Epub 2022 Apr 2.
6
Genistein: A Potent Anti-Breast Cancer Agent.染料木黄酮：一种强效的抗乳腺癌制剂。
Curr Issues Mol Biol. 2021 Oct 10;43(3):1502-1517. doi: 10.3390/cimb43030106.
7
Environmental Exposures during Puberty: Window of Breast Cancer Risk and Epigenetic Damage.青春期的环境暴露：乳腺癌风险和表观遗传损伤的窗口期。
Int J Environ Res Public Health. 2020 Jan 13;17(2):493. doi: 10.3390/ijerph17020493.
8
Environmental exposures during windows of susceptibility for breast cancer: a framework for prevention research.乳腺癌易感期的环境暴露：预防研究框架。
Breast Cancer Res. 2019 Aug 20;21(1):96. doi: 10.1186/s13058-019-1168-2.
9
Mapping Mammary Tumor Traits in the Rat.绘制大鼠乳腺肿瘤特征图谱。
Methods Mol Biol. 2019;2018:249-267. doi: 10.1007/978-1-4939-9581-3_12.
10
Neuronatin is a modifier of estrogen receptor-positive breast cancer incidence and outcome.神经元钙黏蛋白是雌激素受体阳性乳腺癌发病和预后的修饰因子。
Breast Cancer Res Treat. 2019 Aug;177(1):77-91. doi: 10.1007/s10549-019-05307-8. Epub 2019 Jun 4.
单次喂食多环烃诱导的乳腺癌及其抑制作用。
Nature. 1961 Jan 21;189:204-7. doi: 10.1038/189204a0.
4
Relationship between previous reproductive history and chemically induced mammary cancer in rats.大鼠既往生殖史与化学诱导的乳腺癌之间的关系。
Int J Cancer. 1969 May 15;4(3):312-7. doi: 10.1002/ijc.2910040308.
5
Mammary cancer induction by 7,12-dimethylbenz(a)anthracene: relation to age.7,12-二甲基苯并(a)蒽诱发乳腺癌：与年龄的关系
Science. 1969 Aug 22;165(3895):810-1. doi: 10.1126/science.165.3895.810.
6
Effects of multiple pituitary homografts or progesterone on 7,12-dimethylbenz[a]anthracene-induced mammary tumors in rats.多次垂体同种移植或孕酮对7,12-二甲基苯并[a]蒽诱导的大鼠乳腺肿瘤的影响。
J Natl Cancer Inst. 1968 Aug;41(2):465-71.
7
The binding of 7,12-dimethylbenz(a)anthracene to mammary parenchyma DNA and protein in vivo.7,12-二甲基苯并(a)蒽在体内与乳腺实质DNA和蛋白质的结合。
Cancer Res. 1972 Feb;32(2):254-8.
8
Frequency of mammary cell division in relation to age: its significance in the induction of mammary tumors by carcinogen in rats.乳腺细胞分裂频率与年龄的关系：其在大鼠致癌物诱发乳腺肿瘤中的意义。
J Natl Cancer Inst. 1974 Feb;52(2):609-10. doi: 10.1093/jnci/52.2.609.
9
The myothelia (myoepithelial cells). Normal state; regressive changes; hyperplasia; tumors.肌上皮（肌上皮细胞）。正常状态；退行性改变；增生；肿瘤。
Curr Top Pathol. 1970;53:161-220.
10
Myoepithelial cells in carcinoma of human breast.人乳腺癌中的肌上皮细胞。
Am J Pathol. 1966 Aug;49(2):301-7.