Regoeczi E, Hatton M W
Am J Physiol. 1980 May;238(5):R306-10. doi: 10.1152/ajpregu.1980.238.5.R306.
Turnover of transferrin was measured in 62 mammals from 11 species (baboon, dog, goat, guinea pig, man, mouse, pig, rabbit, rat, rhesus monkey, and sheep) using iodinelabeled transferrin of homologous and/or heterologous origin. Protein turnover was determined either from the plasma protein-bound radioactivity curves or from the slopes of total body radiation. The volume of transferrin pool, expressed as equivalent milliliters of plasma, turned over per day correlated closely with species size (r = +0.977). Using the parabolic equation, y = axb, the constants for the relationship between body weight (x) and transferrin turnover (y) were a, 22.845; and b, 0.68. However, species of comparable weights with deviating transferrin turnovers do exist within the boundaries of this relationship. From a limited number of serum transferrin estimations in all species except for rhesus, six species appeared to have transferrin concentrations in a broad middle range (2.5-3.5 mg/ml). By comparison, dog and guinea pig had markedly lower, and pig and rat had markedly higher, serum transferrin concentrations.
利用同源和/或异源来源的碘标记转铁蛋白，对11个物种（狒狒、狗、山羊、豚鼠、人、小鼠、猪、兔、大鼠、恒河猴和绵羊）的62只哺乳动物的转铁蛋白周转率进行了测量。蛋白质周转率可通过血浆蛋白结合放射性曲线或全身辐射斜率来确定。以血浆等效毫升数表示的转铁蛋白池体积，每天的周转率与物种大小密切相关（r = +0.977）。使用抛物线方程y = ax^b，体重（x）与转铁蛋白周转率（y）之间关系的常数为：a，22.845；b，0.68。然而，在这种关系范围内确实存在体重相当但转铁蛋白周转率不同的物种。除恒河猴外，对所有物种进行了有限数量的血清转铁蛋白测定，六个物种的转铁蛋白浓度似乎处于较宽的中等范围（2.5 - 3.5毫克/毫升）。相比之下，狗和豚鼠的血清转铁蛋白浓度明显较低，而猪和大鼠的血清转铁蛋白浓度明显较高。
