Cook I A, Robb A L, Mitchell R, McLaren E A, Urbaniak S, Robertson A E
Br J Haematol. 1980 Apr;44(4):627-34. doi: 10.1111/j.1365-2141.1980.tb08717.x.
The use of frozen washed cells in varying doses in primary Rh immunization is compared to two groups of men with the use of fresh washed cells in a third group. In the first two groups, using frozen cells, doses ranging from 0.5 to 20 ml of whole blood (Group I) are compared with a 200.0 ml dose of red cell concentrate (Group II), while Group III served as a control using a 20 ml dose of fresh washed red cell suspension (9.0 ml concentrated red cell equivalent). The response rate was 93% in Group II compared with only 43% in Group I, suggesting the desirability of using relatively large doses of Rh-positive red cells for primary Rh immunization. The use of frozen washed cells from a special panel for 'booster' injections is also recommended.
将不同剂量的冷冻洗涤细胞用于初次Rh免疫，并与两组男性进行比较，第三组使用新鲜洗涤细胞。在前两组中，使用冷冻细胞，将0.5至20毫升全血剂量（第一组）与200.0毫升红细胞浓缩液剂量（第二组）进行比较，而第三组作为对照组，使用20毫升新鲜洗涤红细胞悬液（相当于9.0毫升浓缩红细胞）。第二组的反应率为93%，而第一组仅为43%，这表明初次Rh免疫使用相对大剂量的Rh阳性红细胞是可取的。还建议使用来自特殊库的冷冻洗涤细胞进行“加强”注射。
