Sex hormone changes in male epileptics.

Mean plasma levels of LH, FSH, PRL, and sex-hormone binding globulin (SHBG) were raised in twenty-seven epileptics on anticonvulsants compared with age matched controls. Sexual activity appeared to be reduced. Anticonvulsant therapy results in raised SHBG levels which may be associated with a lowered free testosterone level as indicated by raised LH levels and lowered sexual activity.