Cooper M J, Baker A L, Moossa A R
Dig Dis Sci. 1980 Jun;25(6):427-32. doi: 10.1007/BF01395506.
To study the mechanism of salicylate-induced choleresis in rhesus monkeys, we utilized animals with indwelling common bile duct catheters under phencyclidine anesthesia. Bile flow, [14C]erythritol clearance (an estimate of canalicular flow), and bile acid secretion were measured during baseline and for 1 1/2 hr during salicylate infusion. Bile flow increased from 91.2 +/- 7.3 ml/24 hr (SEM) to 180.1 +/- 8.0 ml/24 hr (P less than 0.001) with salicylate infusion and [14D]erythritol clearance from 114.5 +/- 8.9 ml/24 hr to 222.3 +/- 10.7 ml/24 hr (P less than 0.001), but bile acid secretion was unchanged, suggesting increased bile acid-independent canalicular bile flow. Salicylate concentration in bile averaged 1.48 +/- 0.08 mmol/liter, and salicylate concentration in extra bile produced by salicylate was unlikely to result in chloeresis of the magnitude observed. [3H]inulin bile-plasma ratios, measured in these same studies, were unchanged after salicylate administration, suggesting that permeability of the biliary tree was not altered. Bile lipid secretion, like bile acid secretion, was unchanged after salicylate administration, so no change occurred in the lithogenic index of the bile. These results demonstrate that salicylate is a potent choleretic in rhesus monkeys because of enhancement of bile acid-independent bile flow. Salicylate produced no change in the lithogenic index of the bile.
为研究水杨酸盐诱导恒河猴胆汁分泌的机制，我们使用了在苯环己哌啶麻醉下留置胆总管导管的动物。在基线期以及水杨酸盐输注期间的1.5小时内，测量胆汁流量、[14C]赤藓糖醇清除率（对胆小管流量的估计）和胆汁酸分泌。输注水杨酸盐后，胆汁流量从91.2±7.3毫升/24小时（标准误）增加到180.1±8.0毫升/24小时（P<0.001），[14D]赤藓糖醇清除率从114.5±8.9毫升/24小时增加到222.3±10.7毫升/24小时（P<0.001），但胆汁酸分泌未改变，提示不依赖胆汁酸的胆小管胆汁流量增加。胆汁中的水杨酸盐浓度平均为1.48±0.08毫摩尔/升，水杨酸盐产生的额外胆汁中的水杨酸盐浓度不太可能导致观察到的胆汁分泌增加幅度。在这些相同研究中测量的[3H]菊粉胆汁-血浆比率在给予水杨酸盐后未改变，提示胆管树的通透性未改变。水杨酸盐给药后，胆汁脂质分泌与胆汁酸分泌一样未改变，因此胆汁的成石指数没有变化。这些结果表明，水杨酸盐是恒河猴中一种有效的利胆剂，因为它增强了不依赖胆汁酸的胆汁流量。水杨酸盐对胆汁的成石指数没有影响。
