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与amdS基因相邻的一个突变，确定了构巢曲霉中正调控基因amdR的作用位点。

A mutation, adjacent to gene amdS, defining the site of action of positive-control gene amdR in Aspergillus nidulans.

作者信息

Hynes M J

出版信息

J Bacteriol. 1980 May;142(2):400-6. doi: 10.1128/jb.142.2.400-406.1980.

DOI:10.1128/jb.142.2.400-406.1980
PMID:6769897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC293985/
Abstract

In Aspergillus nidulans the acetamidase enzyme is inducible by omega-amino acids, sources of acetyl-coenzyme A, and benzoate. The amdR (or intA) gene is a positive-control gene involved in omega-amino acid induction only. A cis-acting mutation amdI93 located in a complex controlling region adjacent to the acetamidase structural gene was found to abolish induction by omega-amino acids but not induction by other sources of induction. As predicted, this mutation was epistatic to constitutive amdR alleles but did not affect the expression of mutations in other regulatory genes.

摘要

在构巢曲霉中，乙酰胺酶可被ω-氨基酸、乙酰辅酶A来源以及苯甲酸盐诱导。amdR（或intA）基因是仅参与ω-氨基酸诱导的正调控基因。发现位于与乙酰胺酶结构基因相邻的一个复杂调控区域中的顺式作用突变amdI93可消除ω-氨基酸诱导，但不影响其他诱导源的诱导作用。正如所预测的，该突变对组成型amdR等位基因是上位性的，但不影响其他调控基因中突变的表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/233c/293985/a3b68e2494b5/jbacter00566-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/233c/293985/a3b68e2494b5/jbacter00566-0034-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/233c/293985/a3b68e2494b5/jbacter00566-0034-a.jpg

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引用本文的文献

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