Stickler D J, Thomas B
J Clin Pathol. 1980 Mar;33(3):288-96. doi: 10.1136/jcp.33.3.288.
A collection of 802 isolates of Gram-negative bacteria causing urinary tract infections was made from general practice, antenatal clinics, and local hospitals. The organisms were tested for their sensitivity to chlorhexidine, cetrimide, glutaraldehyde, phenyl mercuric nitrate, a phenolic formulation, and a proprietary antiseptic containing a mixture of picloxydine, octyl phenoxy polyethoxyethanol, and benzalkonium chloride. Escherichia coli, the major species isolated, proved to be uniformly sensitive to these agents. Approximately 10% of the total number of isolates, however, exhibited a degree of resistance to the cationic agents. These resistant organisms were members of the genera Proteus, Providencia, and Pseudomonas; they were also generally resistant to five, six, or seven antibiotics. It is proposed therefore that an antiseptic policy which involves the intensive use of cationic antiseptics might lead to the selection of a flora of notoriously drug-resistant species.
从普通诊所、产前诊所和当地医院收集了802株引起尿路感染的革兰氏阴性菌分离株。对这些菌株进行了对氯己定、西曲溴铵、戊二醛、硝酸苯汞、一种酚类制剂以及一种含有吡氯腙、辛基苯氧基聚乙氧基乙醇和苯扎氯铵混合物的专利防腐剂的敏感性测试。分离出的主要菌种大肠埃希菌对这些药剂均表现出敏感性。然而，约10%的分离株对阳离子药剂表现出一定程度的抗性。这些耐药菌属于变形杆菌属、普罗威登斯菌属和假单胞菌属；它们通常也对五种、六种或七种抗生素耐药。因此有人提出，大量使用阳离子防腐剂的抗菌策略可能会导致选择出一群具有众所周知耐药性的菌群。
