Van Duzee B F, Sunberg R J, Benedict J J
J Pharm Sci. 1980 May;69(5):599-600. doi: 10.1002/jps.2600690535.
The effect of etidronate disodium on the deformability of human sickle cell erythrocytes was determined. A filtration process that demonstrated changes in trapping of 51Cr-tagged sickle cells in the filtration apparatus was used to evaluate drug effects. Compared to the nontreated control, etidronate disodium [disodium dihydrogen (1-hydroxyethylidene)diphosphonate] reduced the trapping of sickled cells at low concentrations and increased trapping at high concentrations. These results indicate that etidronate disodium alters the deformability of sickled erythrocytes.
测定了依替膦酸二钠对人镰状细胞红细胞变形性的影响。采用一种过滤方法来评估药物效果，该方法可显示51Cr标记的镰状细胞在过滤装置中截留情况的变化。与未处理的对照相比，依替膦酸二钠[二氢(1-羟基亚乙基)二膦酸二钠]在低浓度时减少了镰状细胞的截留，而在高浓度时增加了截留。这些结果表明依替膦酸二钠改变了镰状红细胞的变形性。
