Walker V, Taylor W H
Pediatr Res. 1980 May;14(5):709-14. doi: 10.1203/00006450-198005000-00002.
Gastric juice was collected from 27 children for 9 to 21 hr following cardiac surgery, from 4 further children during and following cardiac surgery, and from 3 children who had not undergone surgery. Each sample was analyzed for hydrogen ion and pepsin content. The pH of the postoperative secretions from 26 patients was 1.25 to 5.30, and the mean hydrogen ion concentration was 60.1 mmol/liter (range, 21.5 to 119.3 mmol/liter). The mean peptic activity (83.0 units/ml; range, 42.4 to 158.4 units/ml) was not age related and was significantly higher than that of the basal and pentagastrin-stimulated secretion and similar to that of vagally stimulated secretion of adults with peptic ulcer. The pepsin:hydrogen ion and pepsin 1:total pepsin ratios also resembled those of vagally stimulated secretion. During the first 90 min of cardiac surgery, the pH of aspirated gastric juice was 1.40 to 4.90, the hydrogen ion concentration was 15.8 to 72.3 mmol/liter, peptic activity was 39.2 to 164.0 units/ml (mean, 97.2 units/ml). Pepsin 1 was present in all samples. Aspirates from 3 unoperated children had low total peptic activity and only trace amounts of pepsin 1. Children from the age of 5.5 months thus have the capacity to secrete all the major pepsins, including pepsin 1. The findings suggest that vagal stimulation of gastric secretion was occurring during the postoperative period.
在心脏手术后9至21小时，收集了27名儿童的胃液；在心脏手术期间及术后，又收集了另外4名儿童的胃液；还收集了3名未接受手术儿童的胃液。对每个样本进行了氢离子和胃蛋白酶含量分析。26例患者术后分泌物的pH值为1.25至5.30，平均氢离子浓度为60.1毫摩尔/升（范围为21.5至119.3毫摩尔/升）。平均胃蛋白酶活性（83.0单位/毫升；范围为42.4至158.4单位/毫升）与年龄无关，且显著高于基础分泌和五肽胃泌素刺激分泌的活性，与患有消化性溃疡的成年人迷走神经刺激分泌的活性相似。胃蛋白酶与氢离子的比例以及胃蛋白酶1与总胃蛋白酶的比例也与迷走神经刺激分泌的比例相似。在心脏手术的前90分钟，吸出的胃液pH值为1.40至4.90，氢离子浓度为15.8至72.3毫摩尔/升，胃蛋白酶活性为39.2至164.0单位/毫升（平均为97.2单位/毫升）。所有样本中均存在胃蛋白酶1。3名未手术儿童的吸出物总胃蛋白酶活性较低，仅含有微量的胃蛋白酶1。因此，5.5个月大的儿童就有能力分泌包括胃蛋白酶1在内的所有主要胃蛋白酶。这些发现表明，术后期间发生了迷走神经对胃分泌的刺激。
