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Biotransformation of 7, 12-dimethylbenz(a)anthracene(DMBA): on the genesis of DMBA-trans-dihydrodiols and DMBA-7- and 12-methylhydroxylated metabolites.

作者信息

Sheikh Y M, Cazer F D, Hart R W, Witiak D T

出版信息

Biochem Biophys Res Commun. 1980 Apr 14;93(3):782-91. doi: 10.1016/0006-291x(80)91145-6.

DOI:10.1016/0006-291x(80)91145-6
PMID:6770856
Abstract
摘要

相似文献

1
Biotransformation of 7, 12-dimethylbenz(a)anthracene(DMBA): on the genesis of DMBA-trans-dihydrodiols and DMBA-7- and 12-methylhydroxylated metabolites.7,12-二甲基苯并(a)蒽(DMBA)的生物转化:关于DMBA反式二氢二醇及DMBA-7-和12-甲基羟基化代谢产物的起源
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2
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Oxidation of the trans-3,4-dihydrodiol metabolites of the potent carcinogen 7,12-dimethylbenz(a)anthracene and other benz(a)anthracene derivatives by 3 alpha-hydroxysteroid-dihydrodiol dehydrogenase: effects of methyl substitution on velocity and stereochemical course of trans-dihydrodiol oxidation.强效致癌物7,12-二甲基苯并(a)蒽及其他苯并(a)蒽衍生物的反式-3,4-二氢二醇代谢物被3α-羟基类固醇-二氢二醇脱氢酶氧化:甲基取代对反式二氢二醇氧化速度和立体化学过程的影响。
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Comparative metabolism and DNA binding of 7,12-dimethylbenz[a]anthracene and its weakly carcinogenic 5-fluoro analog.7,12-二甲基苯并[a]蒽及其弱致癌性5-氟类似物的比较代谢与DNA结合
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The induction of sister chromatid exchanges by dihydrodiols derived from 7,12-dimethylbenz[a]anthracene and 3-methylcholanthrene.由7,12 - 二甲基苯并[a]蒽和3 - 甲基胆蒽衍生的二氢二醇诱导姐妹染色单体交换
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A 7-hydroxymethyl sulfate ester as an active metabolite of 7,12-dimethylbenz[alpha]anthracene.一种7-羟甲基硫酸酯作为7,12-二甲基苯并[a]蒽的活性代谢产物。
Science. 1982 Jan 22;215(4531):403-5. doi: 10.1126/science.6800033.
8
Influence of beta-naphthoflavone on 7,12-dimethylbenz(a)anthracene metabolism, DNA adduction, and tumorigenicity in rainbow trout.β-萘黄酮对虹鳟鱼体内7,12-二甲基苯并(a)蒽代谢、DNA加合物形成及致瘤性的影响
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Metabolism of 7,12-dimethylbenz[a]anthracene and its methyl-hydroxylated metabolites: formation of phenolic metabolites at the 2-positions.
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Metabolic activation of 7,12-dimethylbenz[alpha]anthracene (DMBA) and 7-methylbenz[alpha]anthracene (7-MBA) by rat liver P-450 and sulfotransferase.
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