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秀丽隐杆线虫对7,12-二甲基苯并[a]蒽的代谢

Metabolism of 7,12-dimethylbenz[a]anthracene by Cunninghamella elegans.

作者信息

Wong L K, Dru J, Lin L S, Knapp J

出版信息

Appl Environ Microbiol. 1983 Nov;46(5):1239-42. doi: 10.1128/aem.46.5.1239-1242.1983.

DOI:10.1128/aem.46.5.1239-1242.1983
PMID:6418073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC239550/
Abstract

The metabolites of 7,12-dimethylbenz[a]anthracene (DMBA), a carcinogenic polycyclic aromatic hydrocarbon, in cultures of Cunninghamella elegans were isolated by high-pressure liquid chromatography and characterized by UV spectroscopy and mass spectrometry. The major metabolites were DMBA-trans-8,9-dihydrodiol and DMBA-trans-3,4-dihydrodiol. The 7-hydroxymethyl and the 12-hydroxymethyl derivatives of these dihydrodiol metabolites were also formed. The metabolic profile described in this report contrasts with those obtained in our earlier experiments in which the incubation of DMBA with Pseudomonas aeruginosa and Penicillium notatum produced no dihydrodiol metabolites but only methyl-hydroxylated metabolites.

摘要

7,12-二甲基苯并[a]蒽（DMBA）是一种致癌性多环芳烃，其在雅致小克银汉霉菌培养物中的代谢产物通过高压液相色谱法进行分离，并通过紫外光谱和质谱进行表征。主要代谢产物为DMBA反式-8,9-二氢二醇和DMBA反式-3,4-二氢二醇。这些二氢二醇代谢产物的7-羟甲基和12-羟甲基衍生物也会形成。本报告中描述的代谢谱与我们早期实验中获得的代谢谱形成对比，在早期实验中，DMBA与铜绿假单胞菌和点青霉一起孵育未产生二氢二醇代谢产物，而仅产生甲基羟基化代谢产物。

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本文引用的文献

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Appl Environ Microbiol. 1982 Sep;44(3):682-9. doi: 10.1128/aem.44.3.682-689.1982.
2
Fungal oxidation of 3-methylcholanthrene: formation of proximate carcinogenic metabolites of 3-methylcholanthrene.3-甲基胆蒽的真菌氧化作用：3-甲基胆蒽的近致癌物代谢产物的形成
Chem Biol Interact. 1982 Jan;38(2):161-73. doi: 10.1016/0009-2797(82)90037-0.
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Microbial transformations of 7,2-dimethylbenz[a]anthracene.7,2-二甲基苯并[a]蒽的微生物转化
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4
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Drug Metab Dispos. 1980 Jan-Feb;8(1):28-33.
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Stereochemistry of the hydrolysis products and their acetonides of two stereoisomeric benzo[a]pyrene 7,8-diol 9,10-epoxides.
J Am Chem Soc. 1977 Jul 20;99(15):5124-30. doi: 10.1021/ja00457a036.
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J Biol Chem. 1979 Dec 10;254(23):12174-80.
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Metabolic activation of the carcinogen 7,12-dimethylbenz[a]anthracene for DNA binding.
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