Maurão P A, Machado-Santelli G M, Toledo O M
Biochim Biophys Acta. 1980 May 7;629(2):259-65.
The sulfated glycosaminoglycan content of primary cultures of fibroblasts from guinea-pig embryo kidney is reported. A hybrid chondroitin sulfate comprises approx. 90% of these glycosaminoglycans from the cell coat. Changes in the proportion of labelled heparitin sulfate were also observed after successive subcultures. We postulate a possible correlation between the pattern of glycosaminoglycans and processes of cell selection and cell dedifferentiation in these cultures.
报道了豚鼠胚胎肾成纤维细胞原代培养物中硫酸化糖胺聚糖的含量。一种混合硫酸软骨素约占来自细胞被膜的这些糖胺聚糖的90%。连续传代培养后，还观察到标记硫酸乙酰肝素比例的变化。我们推测在这些培养物中糖胺聚糖模式与细胞选择和细胞去分化过程之间可能存在相关性。
