Baudet M F, Dachet C, Beaumont J L
Clin Exp Immunol. 1980 Feb;39(2):455-60.
Human low density lipoproteins are metabolized by cultured human fibroblasts, through a specific metabolic pathway, which entails the regulation of intracellular cholesterol synthesis. When anti-lipoprotein IgA coming from patients with myeloma, mixed hyperlipidaemia and xanthomatosis were introduced into the system, we observed a decrease of the protein degradation of the LDL molecule, and a disappearance of the regulation of intracellular cholesterol synthesis. In the same system, an anti-lipoprotein IgA from a case of myeloma with mixed hyperlipidaemia, but without xanthomatosis, or control IgG and IgA were inactive and did not modify the LDL pathway.
人低密度脂蛋白通过特定代谢途径由培养的人成纤维细胞进行代谢，该途径涉及细胞内胆固醇合成的调节。当将来自骨髓瘤、混合性高脂血症和黄瘤病患者的抗脂蛋白IgA引入该系统时，我们观察到低密度脂蛋白分子的蛋白质降解减少，并且细胞内胆固醇合成调节消失。在同一系统中，来自一例有混合性高脂血症但无黄瘤病的骨髓瘤患者的抗脂蛋白IgA，或对照IgG和IgA均无活性，且未改变低密度脂蛋白途径。
