Luisi M, Kicóvíc P M, Franchi F
Reproduccion. 1980 Jan-Mar;4(1):77-83.
Twenty healthy male volunteers were randomly allocated to the treatment with either 15 mg/day of epimestrol or placebo for 10 days. The plasma levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T), oestradiol (E2) and prolactin (PRL) were measured before, during and 4 days after the medication by radioimmunoassays. Data were statistically evaluated by means of an analysis of covariance. Circulating LH and FSH, and also T and E2 significantly increased in the epimestrol treated subjects. In the placebo treated subjects no significant changes in the plasma hormone levels were observed. There were no significant changes in the plasma levels of PRL in either group.
20名健康男性志愿者被随机分为两组，分别接受每天15毫克依美雄醇或安慰剂治疗，为期10天。在用药前、用药期间及用药后4天，通过放射免疫分析法测定血浆中促黄体生成素（LH）、促卵泡生成素（FSH）、睾酮（T）、雌二醇（E2）和催乳素（PRL）的水平。数据采用协方差分析进行统计学评估。接受依美雄醇治疗的受试者中，循环LH、FSH以及T和E2显著升高。接受安慰剂治疗的受试者血浆激素水平未观察到显著变化。两组的血浆PRL水平均无显著变化。
