Hager H, Mertens T, Eggers H J
MMW Munch Med Wochenschr. 1980 Apr 25;122(17):619-22.
In October 1978, a 6 day-old child became ill in a maternity ward and died with clinical signs of septicemia. In quick succession, 6 other children fell ill with aseptic meningitis, 5 within the first 10 days post partum and one child 4 weeks old. From these 6 children virus was isolated at different times and from various sites (CSF, pharynx, rectum). 25 isolates were obtained. By cross-neutralization an antigenic variant of Echo virus 11 was identified. Since further isolations were unsuccessful the route of infection was reconstructed from environmental investigation and clinical and serological data in 49 people. A laboratory infection with the agent isolated gave additional opportunities for detailed virological and clinical observations.
1978年10月，一名6天大的婴儿在产科病房发病，死于败血症临床症状。随后，又有6名儿童患上无菌性脑膜炎，其中5名在产后头10天内发病，1名4周大的儿童发病。在这6名儿童中，不同时间从不同部位（脑脊液、咽部、直肠）分离出病毒。共获得25株分离株。通过交叉中和试验，鉴定出埃可病毒11的一个抗原变异株。由于未能进一步分离出病毒，因此根据49人的环境调查、临床和血清学数据重建了感染途径。用分离出的病原体进行实验室感染，为详细的病毒学和临床观察提供了更多机会。
