巴氯芬过量
Baclofen overdose.
作者信息
Lipscomb D J, Meredith T J
出版信息
Postgrad Med J. 1980 Feb;56(652):108-9. doi: 10.1136/pgmj.56.652.108.
Abstract
A 57-year-old woman suffering from multiple sclerosis took an estimated 1500 mg of baclofen. She became deeply unconscious with generalized flaccid muscle paralysis and absent tendon reflexes. Toxicological analysis confirmed the presence of baclofen together with small amounts of paracetamol and glutethimide. Supportive therapy, including assisted ventilation for 3 days, led to complete recovery; anticonvulsant drugs were necessary for the treatment of grand mal fits. The clinical features and treatment of baclofen overdose are discussed.
摘要
一名患有多发性硬化症的57岁女性服用了约1500毫克巴氯芬。她陷入深度昏迷，全身肌肉松弛性麻痹，腱反射消失。毒理学分析证实存在巴氯芬以及少量对乙酰氨基酚和格鲁米特。支持性治疗，包括3天的辅助通气，导致完全康复；治疗癫痫大发作需要使用抗惊厥药物。本文讨论了巴氯芬过量的临床特征和治疗方法。
相似文献
1
Baclofen overdose.巴氯芬过量
Postgrad Med J. 1980 Feb;56(652):108-9. doi: 10.1136/pgmj.56.652.108.
2
An initially unsuspected case of baclofen overdose.一例起初未被怀疑的巴氯芬过量病例。
Am J Crit Care. 2006 Nov;15(6):611-3.
3
Complications of baclofen overdosage.巴氯芬过量的并发症。
Postgrad Med J. 1980 Dec;56(662):865-7. doi: 10.1136/pgmj.56.662.865.
4
[Baclofen intoxication in chronic hemodialysis and kidney transplantation].[慢性血液透析和肾移植中的巴氯芬中毒]
Dtsch Med Wochenschr. 1992 May 8;117(19):733-7. doi: 10.1055/s-2008-1062370.
5
Overdose of lioresal.力奥来素过量
Neurology. 1976 Nov;26(11):1105-6. doi: 10.1212/wnl.26.11.1105.
6
Flaccid paralysis due to chronic baclofen overdosage.
Alcohol Alcohol. 2013 May-Jun;48(3):375. doi: 10.1093/alcalc/agt022. Epub 2013 Mar 15.
7
Coma and Respiratory Failure in a 2-Year-Old Child After Accidental Overdose of Baclofen.一名2岁儿童意外过量服用巴氯芬后出现昏迷和呼吸衰竭
S D Med. 2020 Mar;73(3):106-110.
8
Baclofen overdose: drug experimentation in a group of adolescents.巴氯芬过量：一组青少年中的药物试验
Pediatrics. 1998 Jun;101(6):1045-8. doi: 10.1542/peds.101.6.1045.
9
Physostigmine in the treatment of intrathecal baclofen overdose. Report of three cases.毒扁豆碱治疗鞘内注射巴氯芬过量：三例报告
J Neurosurg. 1989 Aug;71(2):273-5. doi: 10.3171/jns.1989.71.2.0273.
10
First-order elimination kinetics following baclofen overdose.
Ann Emerg Med. 1986 Jul;15(7):843-6. doi: 10.1016/s0196-0644(86)80388-2.
引用本文的文献
1
A selective small-molecule agonist of G protein-gated inwardly-rectifying potassium channels reduces epileptiform activity in mouse models of tumor-associated and provoked seizures.一种G蛋白门控内向整流钾通道的选择性小分子激动剂可降低肿瘤相关性癫痫和诱发性癫痫小鼠模型中的癫痫样活动。
Neuropharmacology. 2025 Mar 1;265:110259. doi: 10.1016/j.neuropharm.2024.110259. Epub 2024 Dec 9.
2
Baclofen overdose with unique cardiovascular effects.巴氯芬过量致独特心血管效应。
BMJ Case Rep. 2024 Sep 30;17(9):e260869. doi: 10.1136/bcr-2024-260869.
3
Toxicologic Confounders of Brain Death Determination: A Narrative Review.脑死亡判定的毒理学混杂因素：一项叙述性综述。
Neurocrit Care. 2021 Jun;34(3):1072-1089. doi: 10.1007/s12028-020-01114-y. Epub 2020 Sep 30.
4
Baclofen overdose mimicking anoxic encephalopathy: a case report and review of the literature.巴氯芬过量酷似缺氧性脑病：一例报告及文献复习
Ther Adv Drug Saf. 2017 May;8(5):165-167. doi: 10.1177/2042098617693571. Epub 2017 Feb 1.
5
Baclofen overdose treated with continuous venovenous hemofiltration.用持续静脉-静脉血液滤过治疗巴氯芬过量。
Eur J Clin Pharmacol. 2015 Mar;71(3):357-61. doi: 10.1007/s00228-014-1802-y. Epub 2015 Jan 9.
6
Baclofen intoxication: a "fun drug" causing deep coma and nonconvulsive status epilepticus--a case report and review of the literature.巴氯芬中毒：一种导致深度昏迷和非惊厥性癫痫持续状态的“娱乐性药物”——病例报告及文献复习。
Eur J Pediatr. 2012 Oct;171(10):1541-7. doi: 10.1007/s00431-012-1780-y. Epub 2012 Jun 23.
7
A benefit-risk assessment of baclofen in severe spinal spasticity.巴氯芬用于严重脊髓痉挛的获益-风险评估
Drug Saf. 2004;27(11):799-818. doi: 10.2165/00002018-200427110-00004.
8
Drug points: Neonatal convulsions after withdrawal of baclofen.药物要点：停用巴氯芬后出现新生儿惊厥。
BMJ. 2001 Jul 14;323(7304):85. doi: 10.1136/bmj.323.7304.85.
9
Respiratory effects of baclofen and 3-aminopropylphosphinic acid in guinea-pigs.巴氯芬和3-氨丙基次膦酸对豚鼠的呼吸影响。
Br J Pharmacol. 1995 Feb;114(4):735-8. doi: 10.1111/j.1476-5381.1995.tb13265.x.
10
Atropine treatment for baclofen overdose.阿托品治疗巴氯芬过量。
Postgrad Med J. 1981 Sep;57(671):580-1. doi: 10.1136/pgmj.57.671.580.
本文引用的文献
1
Lioresal in the treatment of spinal spasticity.
Postgrad Med J. 1972 Oct;48:Suppl 5:30-4.
2
Pharmacological aspects of spasticity with special reference to Lioresal.痉挛的药理学方面，特别提及氯苯氨丁酸
Postgrad Med J. 1972 Oct;48:Suppl 5:13-8.
3
The determination of gamma-amino-beta-(p-chlorophenyl)butyric acid (baclofen) in biological material by gas-liquid chromatography.用气相色谱法测定生物材料中的γ-氨基-β-（对氯苯基）丁酸（巴氯芬）
J Chromatogr. 1976 Feb 18;117(2):399-405. doi: 10.1016/0021-9673(76)80017-9.
4
Routine analysis of barbiturates and some other hypnotic drugs in the blood plasma as an aid to the diagnosis of acute poisoning.
J Chromatogr. 1977 Jan 21;131:131=46. doi: 10.1016/s0021-9673(00)80927-9.
5
Overdose of lioresal.力奥来素过量
Neurology. 1976 Nov;26(11):1105-6. doi: 10.1212/wnl.26.11.1105.
6
Letter: paracetamol measurement.信函：对乙酰氨基酚测量
Lancet. 1975 May 17;1(7916):1147-8. doi: 10.1016/s0140-6736(75)92542-8.
Zotero 插件