Paulson G W
Neurology. 1976 Nov;26(11):1105-6. doi: 10.1212/wnl.26.11.1105.
This is the first reported case of a major overdose of Lioresal (baclofen or CIBA BA-346467). A 29-year-old woman with known Huntington's disease took from 900 to 970 mg of Lioresal, a cogener of gamma amino butyric acid (GABA) used experimentally to treat muscle spasm. She was admitted in deep coma with absent brain stem reflexes and without spontaneous respiration, and she required cardiovascular support. Her pupils were fixed at 3 mm and unreactive for 48 hours. She continued to require intensive support for a total of 72 hours and had one seizure during the recovery phase. Her eventual recovery was complete. No specific antidotes are currently available for overdose of Lioresal and supportive care is the only method of treatment for overdose.
这是首例报道的大剂量服用力奥来素（巴氯芬或CIBA BA - 346467）的病例。一名患有亨廷顿舞蹈症的29岁女性服用了900至970毫克力奥来素，力奥来素是γ-氨基丁酸（GABA）的协同剂，用于实验性治疗肌肉痉挛。她入院时处于深度昏迷状态，脑干反射消失且无自主呼吸，需要心血管支持。她的瞳孔固定在3毫米，48小时内无反应。她总共持续需要72小时的重症支持，并且在恢复期发生了一次癫痫发作。她最终完全康复。目前尚无针对力奥来素过量的特效解毒剂，支持性护理是治疗过量的唯一方法。
