Aozasa K, Uda H
Acta Pathol Jpn. 1980 May;30(3):437-44. doi: 10.1111/j.1440-1827.1980.tb01339.x.
The pattern of lymph node involvement in Waldenström's macröglobulinemia (MG) is described according to clinical and histological materials from 2 biopsy and 4 autopsy cases. The histological features of biopsy were well-differentiated, diffuse, lymphocytic lymphoma in one case (case 1) and sinus histiocytosis (SH) with nodular aggregates of lymphoid cells as observed by the first biopsy in the other case (case 2). An immunofluorescent study of lymph nodes revealed monoclonal proliferation of B lymphocytes (IgM, gamma) in both cases. In case 2, a majority of circulating lymphoid cells bore membrane-bound monoclonal IgM. The histological features of lymph nodes obtained by the second biopsy in case 2 was comparable with the well-differentiated, lymphocytic lymphoma in some nodes, and diffuse and nodular proliferation with preservation of sinuses in the other nodes. The pattern of lymph node involvement of 4 autopsy cases were also analysed. According to these investigations. It is suggested that lymph node showing SH is a pattern of lymph node involvement of MG.
根据2例活检和4例尸检病例的临床及组织学资料，描述了华氏巨球蛋白血症（MG）的淋巴结受累模式。活检的组织学特征为：1例（病例1）表现为高分化弥漫性淋巴细胞淋巴瘤，另1例（病例2）首次活检时可见窦组织细胞增生（SH）伴淋巴细胞结节状聚集。淋巴结免疫荧光研究显示，2例均有B淋巴细胞（IgM、γ）单克隆增殖。病例2中，大多数循环淋巴细胞带有膜结合单克隆IgM。病例2第二次活检获得的淋巴结组织学特征，部分淋巴结与高分化淋巴细胞淋巴瘤相似，其他淋巴结则表现为弥漫性和结节状增殖伴窦结构保留。还分析了4例尸检病例的淋巴结受累模式。根据这些研究，提示表现为SH的淋巴结是MG的一种淋巴结受累模式。
