Howard G M, Jakobiec F A, Trokel S L, Iwamoto T, Jones I S
Am J Ophthalmol. 1978 Jun;85(6):767-71. doi: 10.1016/s0002-9394(14)78103-6.
A 47-year-old white man in apparent good health had diplopia and swelling of the right upper eyelid. Ocular examination showed proptosis of the right eye, together with a large, pulsatile, collapsible mass simulating a vascular neoplasm and involving the right temple as well as the right upper outer quadrant of the orbit. Biopsy of the orbital tumor disclosed a clear-cell carcinoma compatible with a renal primary tumor; subsequent laboratory examination revealed the offending tumor in the left kidney. Renal carcinomas may metastasize to the globe or to the orbit before the primary tumor is recognized. Pulsatile exophthalmos acquired in middle life associated with significant bone destruction represents a constellation of findings most consistent with a metastatic tumor, probably renal carcinoma, caused by the exceedingly rich vascularization of these metastatic deposits.
一名47岁看似健康的白人男性出现复视及右上眼睑肿胀。眼部检查发现右眼突出,伴有一个巨大的、搏动性、可压缩的肿块,类似血管性肿瘤,累及右侧颞部及眼眶右上外象限。眼眶肿瘤活检显示为透明细胞癌,与肾原发性肿瘤相符;随后的实验室检查发现左肾有肿瘤。肾癌可能在原发性肿瘤被发现之前就转移至眼球或眼眶。中年时出现的搏动性眼球突出并伴有明显骨质破坏,这一系列表现最符合转移性肿瘤,很可能是肾癌,原因是这些转移灶血管极其丰富。