Fedorov N A, Iarochkin V S, Kolonina I R, Afonin N I
Biull Eksp Biol Med. 1980 May;89(5):525-7.
A possibility of oxygen transfer by perftorbutylamine emulsion was shown in preliminary experiments on an isolated rabbit heart. 12% perftorbutylamine emulsion was obtained with the aid of the Soviet emulsifier-7% copolymerr of hydroxyethylene and hydroxypropylene. It was supplemented with electrolytes and rheopolyglucin solution at a ratio of 1:4. The parameters of hemodynamics and oxygen body supply were studied in cat experiments involving complete blood replacement by the emulsion (Hct 3%). The life-span of the animals was 3-5 hours. The death was chiefly caused by distrubed circulation consequent on hypovolemia. The fact of excluding red cells that remained in the blood flow bed from the active gas exchange was also ascertained and attributed to PO2 increase in mixed venous blood up to 160mm Hg.
在离体兔心的初步实验中显示了全氟丁胺乳剂进行氧转运的可能性。借助苏联乳化剂——羟乙烯与羟丙烯的7%共聚物，制得12%的全氟丁胺乳剂。按1:4的比例向其中添加电解质和低分子右旋糖酐溶液。在猫的实验中研究了用该乳剂完全置换血液（血细胞比容3%）时的血流动力学参数和机体氧供应情况。动物存活时间为3至5小时。死亡主要是由低血容量导致的循环紊乱引起的。还确定了在血流中留存的红细胞未参与气体交换这一事实，并将其归因于混合静脉血中的氧分压升高至160毫米汞柱。
