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[静脉注射全氟三丁胺乳剂后动物血液及组织中乳酸脱氢酶活性、乳酸及丙酮酸浓度的变化]

[Changes in lactate dehydrogenase activity and lactic and pyruvic acid concentration in the blood and tissues of animals following intravenous administration of perfluorotributylamine emulsions].

作者信息

Afonin N I, Doronina N N, Smelova O S, Ivanova N L, Putiatina T K

出版信息

Vopr Med Khim. 1980 Mar-Apr;26(2):185-7.

PMID:7456348
Abstract

Activity of lactate dehydrogenase (LDH) and concentration of lactate and pyruvate were studied in rat and cat tissues after infusion of perfluorotributylamine emulsion. Administration of the emulsion caused an increase in content of lactate and pyruvate as well as LDH activation in the animal blood and tissues. Tissue hypoxia, responsible for stimulation of glycolytic pathway of carbohydrate metabolism, was apparently developed due to transfer of inadequate amount of oxygen by perfluorotributylamine.

摘要

在输注全氟三丁胺乳剂后，对大鼠和猫组织中的乳酸脱氢酶（LDH）活性、乳酸和丙酮酸浓度进行了研究。乳剂的给药导致动物血液和组织中乳酸和丙酮酸含量增加以及LDH激活。由于全氟三丁胺输送的氧量不足，显然引发了组织缺氧，进而刺激了碳水化合物代谢的糖酵解途径。

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