Cabrol D, Breton M, Berrou E, Visser A, Sureau C, Picard J
Eur J Obstet Gynecol Reprod Biol. 1980 Jun;10(5):281-7. doi: 10.1016/0028-2243(80)90074-x.
A study was made of the modifications of glycosaminoglycans in the uterine cervix and the relationship to gestation. These substances are essential constituents of connective tissue, and a modification of their concentration could affect the physical and chemical characteristics of the cervix. Glycosaminoglycans were extracted from cervical biopsies obtained from pregnant and non-pregnant women. This study showed dermatan sulfte to be quantitatively the most important glycosaminoglycan in the cervix of both the groups studied, and that a significant decrease in the concentration of both dermatan sulfate and chondroitin sulfates occurred in the biopsies obtained just after delivery. This was related to a decrease of collagen in the cervix at the end of gestation, as the proteoglycans containing dermatan sulfate are principally associated with collagen.
对子宫颈中糖胺聚糖的变化及其与妊娠的关系进行了研究。这些物质是结缔组织的重要组成部分，其浓度的改变可能会影响子宫颈的物理和化学特性。从怀孕和未怀孕女性的宫颈活检组织中提取糖胺聚糖。这项研究表明，在两组研究对象的子宫颈中，硫酸皮肤素在数量上是最重要的糖胺聚糖，并且在分娩后立即获得的活检组织中，硫酸皮肤素和硫酸软骨素的浓度均显著降低。这与妊娠末期子宫颈中胶原蛋白的减少有关，因为含有硫酸皮肤素的蛋白聚糖主要与胶原蛋白相关。
