Hawley R S
Genetics. 1980 Mar;94(3):625-46. doi: 10.1093/genetics/94.3.625.
Meiotic exchange was measured in females heterozygous for a normal sequence X chromosome and for each of eleven T(1;4)s and each of sixteen T(1;Y)s. The results indicate that the X chromosome can be divided into five intervals, such that heterozygosity for a breakpoint in one interval strongly suppresses exchange within that interval, but has little or no effect on exchange in other intervals. The boundaries between these intervals are identified and mapped to regions 3C4-6/7, 7A-7E, 11A and proximal to 18C on the standard salivary map; each boundary is located at (or within a small region containing) a major constriction (i.e., a block of intercalary heterochromatin).--Exchange was examined in females heterozygous for translocations broken within the constriction at 11A. The results imply that a boundary occupies only a subregion of the entire constriction and is subdivisible by translocation breakpoints. Several other properties of boundaries have been elucidated. Finally, the relationship of these data to a simple model of meiotic pairing proposed by I. Sandler (1956) and to the role of intercalary heterochromatin in the meiotic process is discussed.
在正常序列X染色体与11个1号染色体与4号染色体易位（T(1;4)）以及16个1号染色体与Y染色体易位（T(1;Y)）的雌性杂合子中测量减数分裂交换。结果表明，X染色体可分为五个区间，使得一个区间内断点的杂合性强烈抑制该区间内的交换，但对其他区间的交换影响很小或没有影响。确定了这些区间之间的边界，并将其定位到标准唾液腺图谱上的3C4 - 6/7、7A - 7E、11A和18C近端区域；每个边界位于（或在包含）一个主要缢痕（即一段居间异染色质）的小区域内。——在11A处缢痕内断裂的易位杂合雌性中检查交换情况。结果表明，一个边界仅占据整个缢痕的一个子区域，并且可被易位断点细分。已经阐明了边界的其他几个特性。最后，讨论了这些数据与I. Sandler（1956年）提出的减数分裂配对简单模型以及居间异染色质在减数分裂过程中的作用之间的关系。
