Kamimura T, Mine Y, Nonoyama S, Nishida M, Goto S, Kuwahara S
Infect Immun. 1980 Jul;29(1):13-6. doi: 10.1128/iai.29.1.13-16.1980.
Polymorphonuclear leukocyte (PMN)-resistant strains of Pseudomonas aeruginosa had the ability to interfere with phagocytosis of Escherichia coli, whereas PMN-sensitive strains of P. aeruginosa did not. When mice were infected with an ordinarily nonpathogenic strain of E. coli, addition of a PMN-resistant strain of P. aeruginosa gave a mortality considerably higher than that obtained with P. aeruginosa alone, whereas addition of a PMN-sensitive strain of P. aeruginosa gave a mortality not different from that observed with P. aeruginosa alone. This increased mortality in mixed infection with E. coli and PMN-resistant P. aeruginosa was obtained by facilitation of tissue invasion by both bacteria from the inoculum site.
多形核白细胞（PMN）抗性的铜绿假单胞菌菌株能够干扰大肠杆菌的吞噬作用，而PMN敏感的铜绿假单胞菌菌株则不能。当小鼠感染通常无致病性的大肠杆菌菌株时，添加PMN抗性的铜绿假单胞菌菌株导致的死亡率显著高于单独使用铜绿假单胞菌时的死亡率，而添加PMN敏感的铜绿假单胞菌菌株导致的死亡率与单独使用铜绿假单胞菌时观察到的死亡率没有差异。在大肠杆菌与PMN抗性铜绿假单胞菌的混合感染中，这种死亡率的增加是通过促进接种部位的两种细菌对组织的侵袭而实现的。
