铜绿假单胞菌对兔多形核白细胞吞噬和杀伤活性的抑制作用：一种多形核白细胞抑制剂的作用机制
Inhibitory effect of Pseudomonas aeruginosa on the phagocytic and killing activity of rabbit polymorphonuclear leukocytes: mechanisms of action of a polymorphonuclear leukocyte inhibitor.
作者信息
Nonoyama S, Kojo H, Mine Y, Nishida M, Goto S, Kuwahara S
出版信息
Infect Immun. 1979 May;24(2):399-403. doi: 10.1128/iai.24.2.399-403.1979.
Abstract
The polymorphonuclear leukocyte (PMN) inhibitor isolated from a strain of Pseudomonas aeruginosa which is resistant to the phagocytic and killing activities of rabbit PMN inhibited migration of PMN and engulfment of latex particles by PMN. In studies of the bactericidal metabolism of PMN, the PMN inhibitor did not inhibit the intracellular activity and extracellular release of lysosomal enzymes. However, the PMN inhibitor caused a decrease of Nitro Blue Tetrazolium reduction. The PMN inhibitor had a cytotoxic effect on PMN and inhibited [14C]tyrosine uptake in intact PMN inhibitor had no inhibitory effect on protein synthesis in cell extracts.
摘要
从一株对兔多形核白细胞（PMN）的吞噬和杀伤活性具有抗性的铜绿假单胞菌中分离出的多形核白细胞抑制剂，可抑制PMN的迁移以及PMN对乳胶颗粒的吞噬。在PMN杀菌代谢的研究中，该PMN抑制剂不抑制溶酶体酶的细胞内活性和细胞外释放。然而，PMN抑制剂导致硝基蓝四氮唑还原减少。PMN抑制剂对PMN具有细胞毒性作用，并抑制完整PMN中[14C]酪氨酸的摄取，而该抑制剂对细胞提取物中的蛋白质合成没有抑制作用。
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