Favier R, Desplanches D, Frutoso J, Grandmontagne M, Flandrois R
Pflugers Arch. 1983 Mar;396(4):269-76. doi: 10.1007/BF01063930.
The fast component of the ventilatory changes that occur at the transition phases of exercise was studied in awake dogs trained to run on a treadmill. Two questions were examined: firstly, is the fast ventilatory component modified by changes in venous return to the lungs, such as those consecutive either to increased work loads or to beta adrenergic blockade?, and secondly, is this component altered by central ventilatory depressants? The results showed that at the onset of exercise, there is no correlation between the instantaneous increment in ventilation and the intensity of exercise, but at the end of the treadmill run, the fall in ventilation is closely linked to the power of the work performed. Ventilatory transients observed either at the start or at the end of exercise remain unaffected by administration of a beta-adrenergic blocking agent. But central depressant effects on ventilation caused by narcotic analgesics or hypnotic drugs altered the breathing pattern of the fast component of exercise-induced ventilatory changes. It is concluded that the instantaneous changes in ventilation occurring at the transition phases of exercise are controlled by mechanoreceptor mechanisms, but cerebral control is superimposed on the reflex control in regulating both tidal volume and breathing rate.
在训练于跑步机上奔跑的清醒犬中，研究了运动转换阶段发生的通气变化的快速成分。研究了两个问题：第一，肺静脉回流的变化，如因工作负荷增加或β肾上腺素能阻滞导致的变化，是否会改变通气的快速成分？第二，这种成分是否会被中枢性通气抑制剂改变？结果表明，在运动开始时，通气的瞬时增量与运动强度之间没有相关性，但在跑步机跑步结束时，通气的下降与所做工作的功率密切相关。在运动开始或结束时观察到的通气瞬变不受β肾上腺素能阻滞剂给药的影响。但是，麻醉性镇痛药或催眠药对通气的中枢抑制作用改变了运动诱导通气变化的快速成分的呼吸模式。得出的结论是，运动转换阶段发生的通气瞬时变化由机械感受器机制控制，但在调节潮气量和呼吸频率方面，大脑控制叠加在反射控制之上。
