与病毒诱导的造血肿瘤相关的猫肾小球肾炎的特征

Glick A D, Horn R G, Holscher M

Am J Pathol. 1978 Aug;92(2):321-32.

Light, electron, and immunofluorescence microscopy on tissues from 63 domestic cats revealed that glomerulonephritis occurred in almost one third of cats with hematopoietic neoplasms of the type linked with feline leukemia virus (FeLV). Glomerular lesions were of the immune complex type with subepithelial, subendothelial, and mesangial dense deposits and reticular aggregates, similar to the nephropathy associated with systemic lupus erythematosus in humans. Evidence that the glomerular lesions may be viral-induced raises the possibility of similar pathogenetic mechanisms in human disease.

对63只家猫的组织进行的光学显微镜、电子显微镜和免疫荧光显微镜检查显示，在几乎三分之一患有与猫白血病病毒（FeLV）相关类型造血肿瘤的猫中发生了肾小球肾炎。肾小球病变为免疫复合物型，有上皮下、内皮和系膜致密沉积物以及网状聚集体，类似于人类系统性红斑狼疮相关的肾病。肾小球病变可能由病毒引起的证据增加了人类疾病中存在类似致病机制的可能性。