Kendrish I N
Probl Endokrinol (Mosk). 1980 May-Jun;26(3):48-53.
Intraperitoneal injection of bromstearate inhibited the oxidation of fatty acids and glyconeogenesis and enhanced the glucose oxidation in intact animals and in rats with diabetes. Bromstearate induced marked hypoglycemia in intact animals, normalized hyperglycemia in rats with alloxan diabetes for 24 hours after the administration. In intact rats daonyl failed to influence fatty acid and glucose oxidation, but induced moderate hypoglycemia. In rats with alloxan diabetes daonyl inhibited oxidation of glucose and, to a lesser extent, of fatty acids, without any changes of hyperglycemia. Inhibitors of fatty acids oxidation are suggested for the pathogenetic therapy of diabetes.
腹腔注射溴硬脂酸盐可抑制完整动物和糖尿病大鼠的脂肪酸氧化及糖异生，并增强葡萄糖氧化。溴硬脂酸盐可使完整动物出现明显低血糖，使四氧嘧啶糖尿病大鼠在给药后24小时内高血糖恢复正常。在完整大鼠中，道诺霉素未能影响脂肪酸和葡萄糖氧化，但可引起中度低血糖。在四氧嘧啶糖尿病大鼠中，道诺霉素抑制葡萄糖氧化，并在较小程度上抑制脂肪酸氧化，但对高血糖无任何影响。脂肪酸氧化抑制剂被推荐用于糖尿病的发病机制治疗。
