[Fatty acid oxidation inhibitors--a new class of antidiabetic drugs. I. Experimental study of hypoglycemic effect of bromstearic acid in comparison with daonil].

Intraperitoneal injection of bromstearate inhibited the oxidation of fatty acids and glyconeogenesis and enhanced the glucose oxidation in intact animals and in rats with diabetes. Bromstearate induced marked hypoglycemia in intact animals, normalized hyperglycemia in rats with alloxan diabetes for 24 hours after the administration. In intact rats daonyl failed to influence fatty acid and glucose oxidation, but induced moderate hypoglycemia. In rats with alloxan diabetes daonyl inhibited oxidation of glucose and, to a lesser extent, of fatty acids, without any changes of hyperglycemia. Inhibitors of fatty acids oxidation are suggested for the pathogenetic therapy of diabetes.