Kendysh I N
Probl Endokrinol (Mosk). 1978 Sep-Oct;24(5):73-6.
Experiments on intact hungry rats showed hydrazine, gluconeongenesis inhibitor, to cause hypoglycemia; it failed to influence glucose utilization and oxidation, and sharply decreased oleate exidation. Hydrazine inhibition of fatty acids (oleate) oxidation and of gluconeogenesis led to practical normalization of blood glucose level, and also to the utilization and oxidation of glucose in alloxan diabetes. It is postulated that agents with an analogous action mechanism could prove to be effective antidiabetic agents.
对饥饿状态下的完整大鼠进行的实验表明，糖原异生抑制剂肼会导致低血糖；它不会影响葡萄糖的利用和氧化，但会大幅降低油酸氧化。肼对脂肪酸（油酸）氧化和糖原异生的抑制作用可使血糖水平实际恢复正常，并且在四氧嘧啶糖尿病中还会促进葡萄糖的利用和氧化。据推测，具有类似作用机制的药物可能会被证明是有效的抗糖尿病药物。
