Kendysh I N
Probl Endokrinol (Mosk). 1980 Jul-Aug;26(4):77-81.
Intraperitoneal injection of hydrocinnamic (beta-phenylpropionic) acid inhibited gluconeogenesis from 14C-1-alanine, 14C-1-oleate oxidation, and intensified 14C-1-glucose oxidation in normal and diabetic rats. Hydrocinnamic acid induced significant hypoglycemia in intact animals and normalized hyperglycemia in rats with alloxan diabetes in the course of 24 hours after the administration. Phenformin proved to decrease glucose oxidation in the intact and diabetic rats, producing no marked effect on fatty acid oxidation, whereas in intact animals it caused moderate hypoglycemia and failed to influence hyperglycemia in the rats with alloxan diabetes. Fatty acid oxidation inhibitors are suggested as means of pathogentic therapy in diabetes mellitus.
腹腔注射氢化肉桂酸（β-苯丙酸）可抑制正常和糖尿病大鼠由14C-1-丙氨酸生成葡萄糖的糖异生作用、14C-1-油酸氧化，并增强14C-1-葡萄糖氧化。氢化肉桂酸在给药后24小时内可使完整动物出现明显低血糖，并使四氧嘧啶糖尿病大鼠的高血糖恢复正常。苯乙双胍可降低完整和糖尿病大鼠的葡萄糖氧化，对脂肪酸氧化无明显影响，而在完整动物中它会引起中度低血糖，对四氧嘧啶糖尿病大鼠的高血糖无影响。脂肪酸氧化抑制剂被认为是糖尿病发病机制治疗的手段。
