Conway de Macario E, Macario A J
Ann Immunol (Paris). 1980 May-Jun;131C(3):397-404.
Priming-memory generation in response to Escherichia coli beta-D-galactosidase occurs without antibody formation in irradiated spleen-cell-transferred C57BL/6J mice, which are genetic low responders to the enzyme. Erythropoiesis abolishes priming-memory generation, so that recipients immunized a few days after cell transfer and erythropoiesis induction do not mount a secondary antibody response. Priming-memory generation in cell recipients immunized 3 days after erythropoiesis induction was less frequent than in controls, whereas no significant differences were found when antigen was given before erythropoiesis induction or 5 days after it. The mean titre of the mice escapint suppression was similar to that of the control mice, which became primed and mounted memory. The titre distribution in both responder groups were also similar, although no high-titered responders were found in the erythropoietic mice. Thus while erythropoiesis induction affects the frequency of priming-memory generation, it does not affect to the same extent the amount of memory generated in those mice escaping suppression. The same distinction was observed when spleen cells from erythropoietic mice, containing 30 to 40% erythroblasts, were transferred into normal mice. However, induction of erythropoiesis in non-irradiated non-cell=transferred mice did not cause suppression.
在受到照射的脾细胞转移的C57BL/6J小鼠（对该酶为遗传性低反应者）中，针对大肠杆菌β-D-半乳糖苷酶的启动-记忆生成在不形成抗体的情况下发生。红细胞生成消除了启动-记忆生成，因此在细胞转移和红细胞生成诱导后几天免疫的受体不会产生二次抗体反应。红细胞生成诱导后3天免疫的细胞受体中的启动-记忆生成比对照组少见，而在红细胞生成诱导前或诱导后5天给予抗原时未发现显著差异。逃避抑制的小鼠的平均滴度与成为启动并产生记忆的对照小鼠相似。两个反应组的滴度分布也相似，尽管在红细胞生成小鼠中未发现高滴度反应者。因此，虽然红细胞生成诱导影响启动-记忆生成的频率，但它对那些逃避抑制的小鼠中产生的记忆量的影响程度不同。当将含有30%至40%成红细胞的红细胞生成小鼠的脾细胞转移到正常小鼠中时，也观察到了同样的区别。然而，在未受照射、未转移细胞的小鼠中诱导红细胞生成不会导致抑制。
