Tsyrlova I G, Chegliakova V V, Kozlov V A
Ontogenez. 1985 Mar-Apr;16(2):143-8.
The cells of liver from the 11-12 day old embryos and of spleen from newborn mice were transplanted to adult syngeneic recipients immunized by the ram erythrocytes. The immune response in the recipient spleens was estimated by the number of antibody-forming cells. The cells of embryonic liver and of newborn spleen suppressed the immune response in recipients to a great extent. The immunodepressive effect obtained was similar to suppression due to the transfer of cell populations from the mice in which erythropoiesis was stimulated by hypoxia of phenylhydrazine. The splenocytes of adult control mice and the cells of spleen from 6-9 day old mice did not exert such an effect. The rabbit antiserum to erythroid cells relieved the suppressor effect of the embryonic liver and neonatal spleen cells, as well as of the other erythropoietic populations. A conclusion is drawn on participation of cells-suppressors of the erythroid nature in the mechanisms of immunological non-responsiveness at the early ontogenetic stages in mice.
将11 - 12日龄胚胎的肝细胞和新生小鼠的脾细胞移植到经公羊红细胞免疫的同基因成年受体中。通过抗体形成细胞的数量来评估受体脾脏中的免疫反应。胚胎肝脏细胞和新生脾脏细胞在很大程度上抑制了受体的免疫反应。所获得的免疫抑制作用类似于因转移来自受苯肼缺氧刺激而产生红细胞生成的小鼠的细胞群体所导致的抑制作用。成年对照小鼠的脾细胞和6 - 9日龄小鼠的脾细胞没有产生这样的效果。兔抗红细胞系细胞抗血清减轻了胚胎肝脏和新生脾脏细胞以及其他红细胞生成群体的抑制作用。得出了关于红细胞系性质的细胞抑制因子参与小鼠早期个体发育阶段免疫无反应机制的结论。
