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[从烧伤感染患者中分离出的铜绿假单胞菌菌株的抗生素耐药性]

[Antibiotic resistance of Pseudomonas aeruginosa strains isolated from patients with infected burns].

作者信息

Adarchenko A A, Zmushko L S, Kostrova N A, Kots N K

出版信息

Antibiotiki. 1980 Aug;25(8):576-9.

PMID:6773473
Abstract

Sensitivity to 15 drugs of 248 P. aeruginosa strains isolated from patients with infected burns was studied by the method of agar dilution. All of the strains were resistant to polymyxin M, ceporin, erythromycin and oleandomycin. Most of the strains were resistant to streptomycin, monomycin, ampicillin and rifadin. Moderate resistance of the strains to carbenicillin, morphocycline, vibramycin, kanamycin, tetraolean and tetracycline was observed: the maximum concentrations of these antibiotics (128 microgram/ml) inhibited the growth of 85, 69, 63, 51.8, 43.6 and 41.2 per cent of the strains respectively. Gentamicin proved to be most active against the strains of P. aeruginosa and inhibited 87 per cent of the strains when used in the therapeutic doses. The study provided recomendation of the drugs for parenteral and local use in treatment of burns infected with P. aeruginosa.

摘要

采用琼脂稀释法研究了从烧伤感染患者中分离出的248株铜绿假单胞菌对15种药物的敏感性。所有菌株对多粘菌素M、头孢菌素、红霉素和竹桃霉素均耐药。大多数菌株对链霉素、单霉素、氨苄青霉素和利福定耐药。观察到菌株对羧苄青霉素、吗啉环素、强力霉素、卡那霉素、四环烷和四环素呈中度耐药:这些抗生素的最大浓度(128微克/毫升)分别抑制了85%、69%、63%、51.8%、43.6%和41.2%的菌株生长。庆大霉素对铜绿假单胞菌菌株最具活性,以治疗剂量使用时可抑制87%的菌株。该研究为治疗铜绿假单胞菌感染烧伤的肠胃外和局部用药提供了药物推荐。

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