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金不会改变II型胶原诱导性关节炎大鼠的关节炎、体液或细胞反应。

Gold does not alter the arthritic, humoral, or cellular responses in rats with type II collagen-induced arthritis.

作者信息

McCune W J, Trentham D E, David J R

出版信息

Arthritis Rheum. 1980 Aug;23(8):932-6. doi: 10.1002/art.1780230809.

DOI:10.1002/art.1780230809
PMID:6773531
Abstract

We assessed the effects of administration of gold sodium thiomalate on the clinical and immunologic manifestations of type II collagen-induced arthritis in rats. Injections of varying doses of gold did not alter these parameters significantly. Thus, there was no evidence in this animal model that gold possesses either antiinflammatory or immunosuppressive properties.

摘要

我们评估了硫代苹果酸金钠给药对大鼠II型胶原诱导性关节炎的临床和免疫表现的影响。注射不同剂量的金并未显著改变这些参数。因此,在这个动物模型中没有证据表明金具有抗炎或免疫抑制特性。

相似文献

1
Gold does not alter the arthritic, humoral, or cellular responses in rats with type II collagen-induced arthritis.金不会改变II型胶原诱导性关节炎大鼠的关节炎、体液或细胞反应。
Arthritis Rheum. 1980 Aug;23(8):932-6. doi: 10.1002/art.1780230809.
2
Effects of various anti-inflammatory drugs on type II collagen-induced arthritis in rats.各种抗炎药物对大鼠II型胶原诱导性关节炎的影响。
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[Auranofin. Mechanism of action, pharmacokinetics and clinical use. Comparison with injectable gold salts].[金诺芬。作用机制、药代动力学及临床应用。与注射用金盐的比较]
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引用本文的文献

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Conditional pharmacology/toxicology V: ambivalent effects of thiocyanate upon the development and the inhibition of experimental arthritis in rats by aurothiomalate (Myocrysin®) and metallic silver.条件药理学/毒理学 V:硫氰酸盐对金硫代苹果酸盐(Myocrysin®)和金属银诱发的实验性关节炎大鼠发展和抑制的双重作用。
Inflammopharmacology. 2013 Aug;21(4):291-300. doi: 10.1007/s10787-013-0173-9. Epub 2013 May 19.
2
Collagen, autoimmunity and disease.胶原蛋白、自身免疫与疾病。
J R Soc Med. 1981 Sep;74(9):703-4. doi: 10.1177/014107688107400924.
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The effects of mesoporphyrin on experimental arthritis in mice.
中卟啉对小鼠实验性关节炎的影响。
Inflamm Res. 1996 Jun;45(6):293-8. doi: 10.1007/BF02280994.
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The influence of a peptide sequence from PF-4 (CT-112) on type II collagen-induced arthritis in mice.
Inflamm Res. 1995 Aug;44 Suppl 2:S125-6. doi: 10.1007/BF01778294.
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Effects of gold sodium thiomalate, cyclosporin A, cyclophosphamide, and placebo on collagen-induced arthritis in rats.硫代苹果酸金钠、环孢素A、环磷酰胺及安慰剂对大鼠胶原诱导性关节炎的影响。
Agents Actions. 1993 Mar;38(3-4):240-6. doi: 10.1007/BF01976216.
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Failure of calcitonin to inhibit collagen-induced arthritis in rats.降钙素未能抑制大鼠胶原诱导的关节炎。
Agents Actions. 1982 Dec;12(5-6):671-3. doi: 10.1007/BF01965077.
7
Assessment of drugs for activity in established type II collagen arthritis.评估药物对已确诊的II型胶原性关节炎的活性。
Agents Actions. 1982 Dec;12(5-6):650-6. doi: 10.1007/BF01965074.
8
Effects of various anti-inflammatory drugs on type II collagen-induced arthritis in rats.各种抗炎药物对大鼠II型胶原诱导性关节炎的影响。
Clin Exp Immunol. 1982 Mar;47(3):579-86.
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Effect of gold salts, D-penicillamine and benoxaprofen on type II collagen-induced arthritis in rats.金盐、青霉胺和苯恶洛芬对大鼠Ⅱ型胶原诱导性关节炎的影响。
Agents Actions. 1984 Jun;14(5-6):707-14. doi: 10.1007/BF01978912.
10
Bisphosphonates in collagen arthritis.双膦酸盐在胶原性关节炎中的应用
Rheumatol Int. 1990;9(6):281-3. doi: 10.1007/BF00541325.