Ray D, Saha K
Am J Trop Med Hyg. 1978 May;27(3):503-7. doi: 10.4269/ajtmh.1978.27.503.
Serum concentrations of IgA, IgG, IgM, IgE, C3 and C4 complement components were estimated in 19 patients with tropical pulmonary eosinophilia (TPE). Thirteen of the patients presented during their first episode of TPE and 6 of them during a relapse of the disease. We found a remarkable elevation of serum IgE level in TPE, which is consistent with earlier reports. In contrast, there was a modest increase in IgM levels and unchanged or even lower levels in IgA and IgG immunoglobulin classes. There seemed to be a direct relationship between IgE level and degree of peripheral blood eosinophilia in TPE. The outstanding finding, however, was a nearly threefold higher mean serum IgE level in patients with relapsing disease as compared to that observed in patients during the primary attack. This is the first reported study of circulating complement components in TPE. A significant rise of serum C3 level was found in these patients; there was no similar elevation of serum C4 component.
对19例热带肺嗜酸性粒细胞增多症（TPE）患者的血清IgA、IgG、IgM、IgE、C3和C4补体成分浓度进行了测定。其中13例患者为首次发作的TPE，6例为疾病复发期。我们发现TPE患者血清IgE水平显著升高，这与早期报告一致。相比之下，IgM水平有适度升高，而IgA和IgG免疫球蛋白类别水平未改变甚至更低。TPE患者的IgE水平与外周血嗜酸性粒细胞增多程度之间似乎存在直接关系。然而，突出的发现是，复发患者的平均血清IgE水平比初次发作患者高出近三倍。这是首次报道的关于TPE患者循环补体成分的研究。这些患者的血清C3水平显著升高；血清C4成分没有类似升高。
