Kapur Y P, Michaels L, El-Sheikh M
Clin Otolaryngol Allied Sci. 1980 Jun;5(3):171-82. doi: 10.1111/j.1365-2273.1980.tb01644.x.
The histopathological changes in human temporal bones are described for 2 cases of kwashiorkor--a protein/calorie malnutrition (PCM) state. There is photographic evidence of severe damge to the middle and inner ears and to the vestibulocochlear nerve. The middle ear shows evidence of chronic otitis media, a common clinical finding in kwashiorkor. Significantly, the round window membranes in both cases showed thickening and infiltration with inflammatory cells. The inner ear showed the loss of cellular elements and hair cell loss in the spiral organ. A marked decrease of spiral ganglion cells and demyelination of the vestibulocochlear nerve were also seen.
本文描述了2例夸休可尔症（一种蛋白质/热量营养不良（PCM）状态）患者颞骨的组织病理学变化。有照片证据显示中耳、内耳及前庭蜗神经受到严重损伤。中耳呈现慢性中耳炎迹象，这是夸休可尔症常见的临床发现。值得注意的是，两例患者的圆窗膜均出现增厚且有炎性细胞浸润。内耳显示细胞成分丧失，螺旋器毛细胞缺失。还可见螺旋神经节细胞显著减少以及前庭蜗神经脱髓鞘。
